Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
about
Cytotoxic enhancement of a bispecific diabody by format conversion to tandem single-chain variable fragment (taFv): the case of the hEx3 diabody.Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokineticsAnti-EGFR scFv tetramer (tetrabody) with a stable monodisperse structure, strong anticancer effect, and a long in vivo half-lifeCrystal structures of mono- and bi-specific diabodies and reduction of their structural flexibility by introduction of disulfide bridges at the Fv interface.A new class of bispecific antibodies to redirect T cells for cancer immunotherapy.Multimerization of anti-(epidermal growth factor receptor) IgG fragments induces an antitumor effect: the case for humanized 528 scFv multimers.Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system.A semi high-throughput method for screening small bispecific antibodies with high cytotoxicityEnhanced Bioactivity of the Anti-LOX-1 scFv Engineered by Multimerization Strategy.Structural considerations for functional anti-EGFR × anti-CD3 bispecific diabodies in light of domain order and binding affinity.
P2860
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P2860
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@ast
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@en
type
label
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@ast
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@en
prefLabel
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@ast
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@en
P2093
P2860
P356
P1476
Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.
@en
P2093
Hiroki Hayashi
Hiroko Kawaguchi
Izumi Kumagai
Keiko Ikoma
Michiaki Unno
Mitsuo Umetsu
Ryutaro Asano
Shintaro Taki
Takeshi Nakanishi
Toshio Kudo
P2860
P304
20844-20849
P356
10.1074/JBC.M110.120444
P407
P577
2010-05-05T00:00:00Z