The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl
about
A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinaseThe Philadelphia chromosome in leukemogenesisLeucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc.Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL.JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.The nuclear translocation assay for intracellular protein-protein interactions and its application to the Bcr coiled-coil domainModeling Philadelphia chromosome positive leukemias.Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cellsJanus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia.From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and BeyondDissecting the molecular mechanism of chronic myelogenous leukemia using murine models.Bcr: a negative regulator of the Bcr-Abl oncoprotein in leukemia.The biology of chronic myelogenous leukemia:mouse models and cell adhesion.The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model.High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.Disruption of Bcr-Abl coiled coil oligomerization by design.SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl.Targeting mutated tyrosine kinases in the therapy of myeloid leukaemias.Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.Targeting ABL and SRC kinases in chronic myeloid leukemia: experience with dasatinib.Effect of Ras inhibition in hematopoiesis and BCR/ABL leukemogenesisDistinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.Aberrant cytokine signaling in leukemia.Re-evaluating the role of BCR/ABL in chronic myelogenous leukemiaThe MORC family: new epigenetic regulators of transcription and DNA damage response.Molecular biology of bcr-abl1-positive chronic myeloid leukemia.An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.Molecular and cellular bases of chronic myeloid leukemia.Natural course and biology of CML.An overview of chronic myeloid leukemia and its animal models.BCR: a new target in resistance mediated by BCR/ABL-315I?Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation.TAT-CC fusion protein depresses the oncogenicity of BCR-ABL in vitro and in vivo through interrupting its oligomerization.MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.Adhesion to stromal cells mediates imatinib resistance in chronic myeloid leukemia through ERK and BMP signaling pathways.The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia.The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms.SHP2 is required for BCR-ABL1-induced hematologic neoplasia.
P2860
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P2860
The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@ast
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@en
type
label
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@ast
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@en
prefLabel
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@ast
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@en
P2093
P2860
P1476
The NH(2)-terminal coiled-coil ...... ive disease in mice by Bcr-Abl
@en
P2093
P2860
P304
P356
10.1128/MCB.21.3.840-853.2001
P407
P577
2001-02-01T00:00:00Z