Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci - Wikidata - wikimedia - TriplyDB

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

http://www.wikidata.org/entity/Q33968470

about

BRCA1 is an essential regulator of heart function and survival following myocardial infarction BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging 53BP1: pro choice in DNA repair Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks Emerging roles of BRCA1 alternative splicing.BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks BRCA1 EXON 11, a CERES (composite regulatory element of splicing) element involved in splice regulation.Oncogenes and tumor suppressor genes BRCA1 pathway function in basal-like breast cancer cells.Understanding missense mutations in the BRCA1 gene: an evolutionary approach.BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.Tumor formation in Brca1 conditional mutant mice.Tumor-initiating cells are not enriched in cisplatin-surviving BRCA1;p53-deficient mammary tumor cells in vivo.Defining a genotoxic profile with mouse embryonic stem cells The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks.Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform.KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer "DNA Binding Region" of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects.Biallelic deleterious BRCA1 mutations in a woman with early-onset ovarian cancer.The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.GT198 Splice Variants Display Dominant-Negative Activities and Are Induced by Inactivating Mutations Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network.Choreography of recombination proteins during the DNA damage response.Preclinical mouse models for BRCA1-associated breast cancer.A mechanism for 1,4-Benzoquinone-induced genotoxicity.Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1 BRCA1 exon 11 alternative splicing, multiple functions and the association with cancer.Links between genome integrity and BRCA1 tumor suppression.Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.Brca1 regulates in vitro differentiation of mammary epithelial cells.BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites.ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.

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Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

http://www.wikidata.org/entity/Q33968470

description

2001 nî lūn-bûn

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2001 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի հունիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Molecular and Cellular Biology

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Impaired DNA damage response i ...... that localizes to nuclear foci

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C J Sarkisian

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C X Deng

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L A Chodosh

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L J Huber

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S R Master

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T W Yang

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

BRCA1 is secreted and exhibits properties of a granin

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

Factors associated with the mammalian RNA polymerase II holoenzyme

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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