Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294.
about
CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasomePhosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation.Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3Multimodal regulation of E2F1 gene expression by progestinsCyclin dependent kinase 2 and the regulation of human progesterone receptor activityRegulation of steroid hormone receptors and coregulators during the cell cycle highlights potential novel function in addition to roles as transcription factorsPost-translational modifications of the progesterone receptorsRegulation of peroxisome proliferator-activated receptor-alpha by MDM2.Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models.Signaling inputs to progesterone receptor gene regulation and promoter selectivity.Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells.Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programsA new strategy for selective targeting of progesterone receptor with passive antagonists.Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7Progesterone and breast cancer.The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention.Human progesterone receptor displays cell cycle-dependent changes in transcriptional activity.Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cellsHuman phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha (ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via association with Src.Peroxisome proliferator-activated receptor gamma activation inhibits progesterone-stimulated human MUC1 expression.Progesterone receptor action: defining a role in breast cancerRole of phosphorylation in progesterone receptor signaling and specificityProgestin upregulates G-protein-coupled receptor 30 in breast cancer cells.Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers.Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation.Progesterone receptors, their isoforms and progesterone regulated transcriptionTracking progesterone receptor-mediated actions in breast cancerDifferential regulation of breast cancer-associated genes by progesterone receptor isoforms PRA and PRB in a new bi-inducible breast cancer cell line.Role of nuclear progesterone receptor isoforms in uterine pathophysiology.Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells.Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancerTip30 deletion in MMTV-Neu mice leads to enhanced EGFR signaling and development of estrogen receptor-positive and progesterone receptor-negative mammary tumors.Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growthck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells.Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.
P2860
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P2860
Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294.
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@ast
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@en
type
label
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@ast
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@en
prefLabel
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@ast
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@en
P2093
P2860
P1476
Transcriptional hyperactivity ...... phosphorylation of serine 294.
@en
P2093
P2860
P304
P356
10.1128/MCB.21.18.6122-6131.2001
P407
P577
2001-09-01T00:00:00Z