OCT1 genetic variants influence the pharmacokinetics of morphine in children.
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PharmGKB summary: very important pharmacogene information for SLC22A1Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: Knowledge deficits and prospects for future research.ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1.ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter.Pharmacogenomics and adverse drug reactions in children.Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions.Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions.OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children.Causes and Consequences of Variability in Drug Transporter Activity in Pediatric Drug Therapy.Mechanistic Population Pharmacokinetics of Morphine in Neonates With Abstinence Syndrome After Oral Administration of Diluted Tincture of Opium.Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children.OCT1 pharmacogenetics in pain management: is a clinical application within reach?Prior opioid exposure influences parents' sharing of their children's CYP2D6 research results.Opioid-related adverse effects in children undergoing surgery: unequal burden on younger girls with higher doses of opioids.Polymorphic OCT1: a valid biomarker, but for which drugs?Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine.Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency.Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.Intravenous morphine versus intravenous paracetamol after cardiac surgery in neonates and infants: a study protocol for a randomized controlled trial.Genetic Heterogeneity of SLC22 Family of Transporters in Drug Disposition.OCT1 mediates hepatic uptake of sumatriptan and loss-of-functionOCT1polymorphisms affect sumatriptan pharmacokinetics
P2860
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P2860
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
@ast
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
@en
type
label
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
@ast
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
@en
prefLabel
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
@ast
OCT1 genetic variants influence the pharmacokinetics of morphine in children.
@en
P2093
P2860
P356
P1433
P1476
OCT1 genetic variants influence the pharmacokinetics of morphine in children
@en
P2093
Hope R Esslinger
Pornswan Ngamprasertwong
Senthilkumar Sadhasivam
Tomoyuki Mizuno
Tsuyoshi Fukuda
Vanessa Olbrecht
Vidya Chidambaran
P2860
P304
P356
10.2217/PGS.13.94
P577
2013-07-01T00:00:00Z