The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.
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Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2Crystal structure of human cytochrome P450 2D6Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brainDifferential oxidation of two thiophene-containing regioisomers to reactive metabolites by cytochrome P450 2C9Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokersStructural diversity of eukaryotic membrane cytochrome p450sStructural insight into the altered substrate specificity of human cytochrome P450 2A6 mutantsCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray CrystallographyCrystal Structure of H2O2-dependent Cytochrome P450SP with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE POSITIONInvestigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo PotencyStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenaseVariations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyStructure and dynamics of the membrane-bound cytochrome P450 2C9Identifying cytochrome p450 functional networks and their allosteric regulatory elementsDistal effect of amino acid substitutions in CYP2C9 polymorphic variants causes differences in interatomic interactions against (S)-warfarinThe curious case of benzbromarone: insight into super-inhibition of cytochrome P450Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions.Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Comparative QSAR analyses of competitive CYP2C9 inhibitors using three-dimensional molecular descriptors.Potentially increasing the metabolic stability of drug candidates via computational site of metabolism prediction by CYP2C9: The utility of incorporating protein flexibility via an ensemble of structuresPredicting in vivo drug interactions from in vitro drug discovery data.Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9.Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like moleculesExplaining the atypical reaction profiles of heme enzymes with a novel mechanistic hypothesis and kinetic treatmentIn Silico Investigation of Cytochrome P450 2C9 in relation to Aging Using Traditional Chinese Medicine.Structural and functional insights into polymorphic enzymes of cytochrome P450 2C8.Cytochrome P450 reductase: a harbinger of diffusible reduced oxygen speciesCYP2C8 exists as a dimer in natural membranes.Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding.Recent Structural Insights into Cytochrome P450 Function.Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adductionBioactivities of berberine metabolites after transformation through CYP450 isoenzymes.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.
P2860
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P2860
The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@ast
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@en
type
label
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@ast
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@en
prefLabel
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@ast
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@en
P2093
P2860
P356
P1476
The structure of human cytochr ...... rbiprofen at 2.0-A resolution.
@en
P2093
C David Stout
Christine Yang
Eric F Johnson
Guillaume A Schoch
Jason K Yano
Keith J Griffin
Michael R Wester
P2860
P304
35630-35637
P356
10.1074/JBC.M405427200
P407
P577
2004-06-04T00:00:00Z