Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
about
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferaseStructure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate PotentialKinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyXAsexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplificationsTargeting purine and pyrimidine metabolism in human apicomplexan parasitesCatalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysisBioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China.Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network.Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in miceAntimalarial drug discovery: efficacy models for compound screening.Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenaseGenetic modification of the diarrhoeal pathogen Cryptosporidium parvum.Folate metabolism as a source of molecular targets for antimalarials.Cloning, expression, and characterization of Babesia gibsoni dihydrofolate reductase-thymidylate synthase: inhibitory effect of antifolates on its catalytic activity and parasite proliferation.Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.Recent highlights in antimalarial drug resistance and chemotherapy research.Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in miceNovel antimalarial drug targets: hope for new antimalarial drugs.Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance.Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery.Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.
P2860
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P2860
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Potent and selective activity ...... against Plasmodium falciparum.
@ast
Potent and selective activity ...... against Plasmodium falciparum.
@en
type
label
Potent and selective activity ...... against Plasmodium falciparum.
@ast
Potent and selective activity ...... against Plasmodium falciparum.
@en
prefLabel
Potent and selective activity ...... against Plasmodium falciparum.
@ast
Potent and selective activity ...... against Plasmodium falciparum.
@en
P2093
P2860
P1476
Potent and selective activity ...... against Plasmodium falciparum.
@en
P2093
P2860
P304
P356
10.1128/AAC.44.4.1047-1050.2000
P407
P577
2000-04-01T00:00:00Z