Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
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VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-IFarnesyl transferase inhibitor resistance probed by target mutagenesisResistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferaseEfficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein FarnesyltransferaseStructural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein FarnesyltransferaseThematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylationThe susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposingAsexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplificationsEsterase mutation is a mechanism of resistance to antimalarial compoundsIn vitro adaptation of Plasmodium falciparum reveal variations in cultivability.Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.In vitro selection of Plasmodium falciparum drug-resistant parasite lines.Therapeutic intervention based on protein prenylation and associated modificationsStructure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agentsMacrophages and Cell-Cell Spread of HIV-1.Drug discovery for malaria: a very challenging and timely endeavorAntimalarial drugs: current status and new developments.Protein geranylgeranyltransferase-I of Trypanosoma cruzi.Prospects for the treatment of drug-resistant malaria parasites.Anti-infectives targeting the isoprenoid pathway of Toxoplasma gondii.Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasitesExpression of functional Plasmodium falciparum enzymes using a wheat germ cell-free systemTarget identification and validation of novel antimalarials.Dynamics of ESCRT proteins.Isoprenoid biosynthesis in Plasmodium falciparum.Molecular dynamic simulations and structure-based pharmacophore development for farnesyltransferase inhibitors discovery.Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase.Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.Three-dimensional quantitative structure-farnesyltransferase inhibition analysis for some diaminobenzophenones.CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans.Structure-based binding between protein farnesyl transferase and PRL-PTP of malaria parasite: an interaction study of prenylation process in Plasmodium.Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action.In silicoanalysis reveals the anti-malarial potential of quinolinyl chalcone derivativesBinding mode of conformations and structure-based pharmacophore development for farnesyltransferase inhibitors
P2860
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P2860
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@en
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@nl
type
label
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@en
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@nl
prefLabel
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@en
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@nl
P2093
P2860
P921
P356
P1476
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
@en
P2093
Christophe L M J Verlinde
Debopam Chakrabarti
John White
Kevin Bauer
Kohei Yokoyama
Laxman Nallan
Oliver Hucke
Pradipsinh K Rathod
Richard T Eastman
Wesley C Van Voorhis
P2860
P304
13554-13559
P356
10.1074/JBC.M413556200
P407
P577
2005-01-20T00:00:00Z