Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.

Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.

http://www.wikidata.org/entity/Q33980306

about

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases Modeling the complex pathology of Alzheimer's disease in Drosophila Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Drosophila models of tauopathies: what have we learned?Global analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitro The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation Early glycogen synthase kinase-3β and protein phosphatase 2A independent tau dephosphorylation during global brain ischaemia and reperfusion following cardiac arrest and the role of the adenosine monophosphate kinase pathway Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer's disease.Modelling tauopathies in Drosophila: insights from the fruit fly.MAPping out distribution routes for kinesin couriers.Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.Shedding Light on Alzheimer's β-Amyloidosis: Photosensitized Methylene Blue Inhibits Self-Assembly of β-Amyloid Peptides and Disintegrates Their Aggregates.Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.Luteolin reduces zinc-induced tau phosphorylation at Ser262/356 in an ROS-dependent manner in SH-SY5Y cells.Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease.Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats.Ginkgo biloba extract (Egb761) attenuates zinc-induced tau phosphorylation at Ser262 by regulating GSK3β activity in rat primary cortical neurons.Insights into amyloid disease from fly models.An AMPK-dependent regulatory pathway in tau-mediated toxicity.Drosophila melanogaster: Deciphering Alzheimer’s Disease.Imidazole improves cognition and balances Alzheimer's-like intracellular calcium homeostasis in transgenic Drosophila model.Ionizing radiation causes increased tau phosphorylation in primary neurons.Drosophila melanogaster: Deciphering Alzheimer's Disease.De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease.Phenotypic differences between Drosophila Alzheimer’s disease models expressing human Aβ42 in the developing eye and brain

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P2860

Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.

http://www.wikidata.org/entity/Q33980306

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Human Molecular Genetics

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Anthony Gatt

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Kanae Iijima-Ando

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Koichi Iijima

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P2860

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

The genetic epidemiology of neurodegenerative disease.

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

Mushroom body memoir: from maps to models

Nuclear dynamics of PCNA in DNA replication and repair.

Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease

Alzheimer's disease: genes, proteins, and therapy

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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2947-2957

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10.1093/HMG/DDQ200

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15

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19

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phosphorylation

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