Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

http://www.wikidata.org/entity/Q33687072

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Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease Loss of Polo ameliorates APP-induced Alzheimer's disease-like symptoms in Drosophila Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling Modeling the complex pathology of Alzheimer's disease in Drosophila Ageing increases vulnerability to aβ42 toxicity in Drosophila Lithium suppresses AÎ² pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.Lack of evidence of the interaction of the Aβ peptide with the Wnt signaling cascade in Drosophila models of Alzheimer's disease A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.GSK-3 in Neurodegenerative Diseases.GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke.A commonly used Drosophila model of Alzheimer's disease generates an aberrant species of amyloid-β with an additional N-terminal glutamine residue.Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons.Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila.Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo.Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer's Disease and Down Syndrome Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models.Presynaptic Aβ40 prevents synapse addition in the adult Drosophila neuromuscular junction.Deletion of endogenous Tau proteins is not detrimental in Drosophila.An exploration of the potential mechanisms and translational potential of five medicinal plants for applications in Alzheimer's disease.Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: implications for synaptic dysfunction and neuronal damage pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity.A holidic medium for Drosophila melanogaster.Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ1-42.Six psychotropics for pre-symptomatic & early Alzheimer's (MCI), Parkinson's, and Huntington's disease modification.Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis Lithium in neuropsychiatry: a 2010 update.The power and richness of modelling tauopathies in Drosophila.Interaction between pathogenic proteins in neurodegenerative disorders.Modelling tauopathies in Drosophila: insights from the fruit fly.Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.

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Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

http://www.wikidata.org/entity/Q33687072

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2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Hrvoje Augustin

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Iain Rogers

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Marcus J Allen

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Oyinkan Sofola

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P2860

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

A Drosophila model of Parkinson's disease

Phosphate-binding tag, a new tool to visualize phosphorylated proteins

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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9

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Simon Lovestone

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46170841

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20824130

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Alzheimer's disease

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2932684

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