Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.
about
Analysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γRibonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase.Biochemical analysis of human POLG2 variants associated with mitochondrial disease.Biochemical analysis of the G517V POLG variant reveals wild-type like activity.Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimersPOLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γA p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits.Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations.Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome
P2860
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P2860
Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Purification and functional ch ...... a harboring disease mutations.
@ast
Purification and functional ch ...... a harboring disease mutations.
@en
type
label
Purification and functional ch ...... a harboring disease mutations.
@ast
Purification and functional ch ...... a harboring disease mutations.
@en
prefLabel
Purification and functional ch ...... a harboring disease mutations.
@ast
Purification and functional ch ...... a harboring disease mutations.
@en
P2093
P2860
P1433
P1476
Purification and functional ch ...... ma harboring disease mutations
@en
P2093
Matthew J Longley
Matthew J Young
Rajesh Kasiviswanathan
P2860
P304
P356
10.1016/J.YMETH.2010.02.015
P577
2010-02-20T00:00:00Z