Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
about
Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kineticsPolymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γThe Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity against HIV-2 than against HIV-1.Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors.Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.
P2860
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P2860
Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
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2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@ast
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@en
type
label
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@ast
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@en
prefLabel
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@ast
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@en
P2093
P2860
P356
P1476
Balancing antiviral potency an ...... r HIV-1 reverse transcriptase.
@en
P2093
Christal D Sohl
Hiroaki Mitsuya
Karen S Anderson
Masanori Baba
Rajesh Kasiviswanathan
Ugo Pradere
P2860
P304
P356
10.1124/MOL.112.078758
P577
2012-04-18T00:00:00Z