The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
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The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectorsMST1 is a multifunctional caspase-independent inhibitor of androgenic signaling.Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptorProhibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genesStructure and function of steroid receptor AF1 transactivation domains: induction of active conformationsDevelopment of a second-generation antiandrogen for treatment of advanced prostate cancerThe cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growthExpanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)Ligand-specific dynamics of the androgen receptor at its response element in living cellsChemistry and structural biology of androgen receptorTherapeutic Rationales, Progresses, Failures, and Future Directions for Advanced Prostate CancerStructural insights into corepressor recognition by antagonist-bound estrogen receptorsX-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding InterfaceChanges in the transcriptome of the human endometrial Ishikawa cancer cell line induced by estrogen, progesterone, tamoxifen, and mifepristone (RU486) as detected by RNA-sequencingTranscriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cellsEstrogen receptors recruit SMRT and N-CoR corepressors through newly recognized contacts between the corepressor N terminus and the receptor DNA binding domain.Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotypeNCoR1 mediates papillomavirus E8;E2C transcriptional repressionCooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor.The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.Androgen receptor functions in prostate cancer development and progressionElevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion.High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer.A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude miceComplex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines.Structural basis for computational screening of non-steroidal androgen receptor ligands.In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancerNuclear receptor corepressor complexes in cancer: mechanism, function and regulationConversion of abiraterone to D4A drives anti-tumour activity in prostate cancer.Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells.Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells.The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity.Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity.Radiation, inflammation, and immune responses in cancerEstrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor.Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns.Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.
P2860
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P2860
The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
description
2004 nî lūn-bûn
@nan
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The androgen receptor recruits ...... androgen receptor antagonists.
@ast
The androgen receptor recruits ...... androgen receptor antagonists.
@en
type
label
The androgen receptor recruits ...... androgen receptor antagonists.
@ast
The androgen receptor recruits ...... androgen receptor antagonists.
@en
prefLabel
The androgen receptor recruits ...... androgen receptor antagonists.
@ast
The androgen receptor recruits ...... androgen receptor antagonists.
@en
P2093
P2860
P356
P1476
The androgen receptor recruits ...... androgen receptor antagonists.
@en
P2093
Anthony N Hollenberg
Eunis Choi
Inna Astapova
Larissa J Lee
Manon C Verhoeven
Myles C Hodgson
Shinta Cheng
Steven P Balk
P2860
P304
P356
10.1074/JBC.M408972200
P407
P577
2004-12-14T00:00:00Z