Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain.
about
Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formationStructural Maturation of HIV-1 Reverse Transcriptase-A Metamorphic Solution to Genomic InstabilityConservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patientsThe y271 and i274 amino acids in reverse transcriptase of human immunodeficiency virus-1 are critical to protein stabilityClicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage siteReduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.The nature of the N-terminal amino acid residue of HIV-1 RNase H is critical for the stability of reverse transcriptase in viral particles.Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.The p66 immature precursor of HIV-1 reverse transcriptase.Asymmetric conformational maturation of HIV-1 reverse transcriptase.Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase.Unfolding the HIV-1 reverse transcriptase RNase H domain--how to lose a molecular tug-of-war.3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.Clinical significance of human immunodeficiency virus type 1 replication fitness.The N-end rule and retroviral infection: no effect on integrase.3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions.Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor.Mechanism of HIV antiretroviral drugs progress toward drug resistance.Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.Induced maturation of human immunodeficiency virus.Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention.Role of the foamy virus Pol cleavage site in viral replication.Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.
P2860
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P2860
Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Virion instability of human im ...... p51 and the RT RNase H domain.
@ast
Virion instability of human im ...... p51 and the RT RNase H domain.
@en
type
label
Virion instability of human im ...... p51 and the RT RNase H domain.
@ast
Virion instability of human im ...... p51 and the RT RNase H domain.
@en
prefLabel
Virion instability of human im ...... p51 and the RT RNase H domain.
@ast
Virion instability of human im ...... p51 and the RT RNase H domain.
@en
P2860
P1433
P1476
Virion instability of human im ...... p51 and the RT RNase H domain.
@en
P2093
Michael A Parniak
Michael E Abram
P2860
P304
11952-11961
P356
10.1128/JVI.79.18.11952-11961.2005
P407
P577
2005-09-01T00:00:00Z