Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.

Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.

Item
http://www.wikidata.org/entity/Q37452008
HIV-1 reverse transcriptionStructure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.Reduced fitness in cell culture of HIV-1 with nonnucleoside reverse transcriptase inhibitor-resistant mutations correlates with relative levels of reverse transcriptase content and RNase H activity in virions.The nature of the N-terminal amino acid residue of HIV-1 RNase H is critical for the stability of reverse transcriptase in viral particles.Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients.The N-end rule and retroviral infection: no effect on integrase.Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.Mechanisms involved in the selection of HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with nucleoside analogue therapy failure.Induced maturation of human immunodeficiency virus.Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy
P2860

Mutations in the thumb allow human immunodeficiency virus type 1 reverse transcriptase to be cleaved by protease in virions.

Item
http://www.wikidata.org/entity/Q37452008
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutations in the thumb allow h ...... leaved by protease in virions.
@en
Mutations in the thumb allow h ...... leaved by protease in virions.
@nl
type
label
Mutations in the thumb allow h ...... leaved by protease in virions.
@en
Mutations in the thumb allow h ...... leaved by protease in virions.
@nl
prefLabel
Mutations in the thumb allow h ...... leaved by protease in virions.
@en
Mutations in the thumb allow h ...... leaved by protease in virions.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Mutations in the thumb allow h ...... leaved by protease in virions.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932