An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
about
P1343
Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defectsSpecies-specific transcription in mice carrying human chromosome 21Comparative studies of gene expression and the evolution of gene regulationConcise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic diseaseDown syndrome: searching for the genetic culpritsOn the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndromeProspects for Improving Brain Function in Individuals with Down SyndromeImpaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null miceSupplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trialDissecting Alzheimer disease in Down syndrome using mouse modelsA pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challengesThe replication domain model: regulating replicon firing in the context of large-scale chromosome architectureMouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesDown Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 HomologuesHippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndromeCis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergenceNovel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells.Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media.The use of mouse models to understand and improve cognitive deficits in Down syndrome.Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1).A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouseEffects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.Alzheimer disease models and human neuropathology: similarities and differencesLithium rescues synaptic plasticity and memory in Down syndrome mice.Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21.Understanding the basis for Down syndrome phenotypes.Modeling chromosomes in mouse to explore the function of genes, genomic disorders, and chromosomal organizationAn additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.The expanding role of mouse genetics for understanding human biology and diseaseImpairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndromeGreen tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes.Molecular basis of pharmacotherapies for cognition in Down syndromeMeiotic behavior of aneuploid chromatin in mouse models of Down syndrome.Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome.Ohnologs in the human genome are dosage balanced and frequently associated with disease.Translating dosage compensation to trisomy 21
P2860
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P2860
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@ast
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@en
type
label
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@ast
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@en
prefLabel
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@ast
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@en
P2093
P2860
P50
P356
P1433
P1476
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.
@en
P2093
Abdul Sesay
Aideen O'Doherty
Claire Mulligan
Dean Nizetic
Deborah J Henderson
Jacqueline M Linehan
Lesley Vanes
Mick L Errington
Sandra Ruf
Sebastian Brandner
P2860
P304
P356
10.1126/SCIENCE.1114535
P407
P4510
P577
2005-09-01T00:00:00Z