Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide.
about
Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathwaysPyrazinamide inhibits trans-translation in Mycobacterium tuberculosisA balancing act: efflux/influx in mycobacterial drug resistanceMycobacterium tuberculosis Rv0899 Adopts a Mixed α/β-Structure and Does Not Form a Transmembrane β-BarrelpncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, CanadaStudy of the structure-activity relationships for the pyrazinamidase (PncA) from Mycobacterium tuberculosisThe molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosisTwo-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinumExpression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environmentsBiosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilliBiochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamideReplication rates of Mycobacterium tuberculosis in human macrophages do not correlate with mycobacterial antibiotic susceptibilityUnravelling the Secrets of Mycobacterial Cidality through the Lens of AntisenseMechanisms of Pyrazinamide Action and ResistanceTuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.Systematic analysis of pyrazinamide-resistant spontaneous mutants and clinical isolates of Mycobacterium tuberculosis.Differences in Interactions of Benzoic Acid and Benzoate with Interfaces.Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory.Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.Expression of Mycobacterium smegmatis pyrazinamidase in Mycobacterium tuberculosis confers hypersensitivity to pyrazinamide and related amides.Requirement of the mymA operon for appropriate cell wall ultrastructure and persistence of Mycobacterium tuberculosis in the spleens of guinea pigs.Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculosis drug pyrazinamide.Evaluation of colorimetric methods using nicotinamide for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis.Molecular epidemiological study of pyrazinamide-resistance in clinical isolates of mycobacterium tuberculosis from South India.Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosisAsnB is involved in natural resistance of Mycobacterium smegmatis to multiple drugsUncoupling Environmental pH and Intrabacterial Acidification from Pyrazinamide Susceptibility in Mycobacterium tuberculosisNicotinamidase/pyrazinamidase of Mycobacterium tuberculosis forms homo-dimers stabilized by disulfide bonds.Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells.Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase IComparative evaluation of Löwenstein-Jensen proportion method, BacT/ALERT 3D system, and enzymatic pyrazinamidase assay for pyrazinamide susceptibility testing of Mycobacterium tuberculosisPyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives.The association between sterilizing activity and drug distribution into tuberculosis lesions.Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages.
P2860
Q24538909-59290E9B-F9C3-4D2B-9999-2A1363A9D9A7Q24539226-30C7DD45-3152-4275-9442-EF6346BB12A8Q24609567-E68CC4ED-9B46-43FD-9B9D-7B3D51C117B3Q24644870-099EE9EC-32AD-4ADF-8142-C1E2665F897EQ27660097-F0D5DD59-34B6-4D87-B480-464159999306Q28343917-9DCF3056-C6A9-4525-B667-DF3D32375D55Q28347549-EA773DCF-361F-4044-A5F9-6E9C15540028Q28362898-ACC18861-F9DC-47D6-9EBB-E92599251512Q28478890-EDB45F56-1129-4F7C-8043-1A0889D3E121Q28486644-BE6E49F0-FB06-4297-B42B-D3D3303652B5Q28487010-3067A7FA-DABE-4C63-801C-CE9CDEA8BA98Q28539893-53216C28-0B11-4EFC-AD9C-B964DDDEC700Q28544850-C6EB7858-94D2-4651-BBAE-4A3820E1620DQ28551800-A7667D2F-4C36-4DA1-8B39-745AD5432163Q29304444-9A9D0E66-A2B1-4B32-8171-404BE74638C6Q30373724-F3B2638B-7D16-4C85-BB14-40C3460632ADQ30419570-BA1046B2-8752-4C52-A5E5-143F13A44AD7Q31119119-DE3B1AF1-88AF-4CAA-9BAB-6B374BD6A8D0Q33677221-CD4BF685-BE0D-498C-8A2F-33EE87E5881DQ33704769-EB95CAFB-D837-47AD-A552-DBE25EE8F8B2Q33752491-0DB86177-E72A-4823-A59D-530427DF688EQ33787470-3316A0E2-89A0-4DDD-9F25-782F51E99FBAQ33855579-47F63092-F0DE-47B8-BF9C-3B0BA98A3DB6Q33976410-236720D9-7F62-4150-A19E-846C0ADFB97EQ34046282-97192D5F-B96A-425E-9540-1AF2D1EEAA63Q34061907-FF0C0905-81E3-421D-BC1A-B877A634353BQ34113610-4DCA3E4D-EC8F-4BC2-85AB-F0C9A3A416CFQ34301633-7C5DB56B-2BD7-4E05-AC11-B0C8717A1AABQ34494098-BE736495-2CF2-4604-8F33-59EF395692BAQ34644335-0B86713B-AE58-4CBE-9CA1-6B347BB65D87Q34737913-C2619BB4-5A68-4389-B4CE-64F7AA696B2AQ35011151-7BBA46C3-C5D5-418F-8773-45F7C117443CQ35168078-6D2F723E-88CE-4129-97E1-F26BA91F3704Q35690257-B72BE5EE-F68F-4C71-A38E-B42CF36256F4Q35718261-EE98D852-6C50-4FD1-A4F7-36DC1BA0F08BQ35743972-6ABE17AF-ED7F-4D61-A9BA-229B45A842E5Q35765601-B7D6B574-AE37-48D6-BA65-30E4E6B21438Q35879089-9956539B-63B7-4493-BEC9-DE69076B96E9Q36086220-7C6BC981-3809-4EE3-9AF9-955D2FA1FD66Q36290784-451A9E60-C40C-41DF-AAAF-A6402F5B5C35
P2860
Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide.
description
1999 nî lūn-bûn
@nan
1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@ast
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@en
type
label
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@ast
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@en
prefLabel
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@ast
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@en
P2093
P2860
P1476
Role of acid pH and deficient ...... tuberculosis to pyrazinamide.
@en
P2093
P2860
P304
P407
P577
1999-04-01T00:00:00Z