Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. - Wikidata - wikimedia - TriplyDB

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.

http://www.wikidata.org/entity/Q33991690

about

Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition?Evolving concepts in cancer therapy through targeting sphingolipid metabolism A review of ceramide analogs as potential anticancer agents BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma A critical dose of doxorubicin is required to alter the gene expression profiles in MCF-7 cells acquiring multidrug resistance Re-configuration of sphingolipid metabolism by oncogenic transformation.Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Incorporation of Fluorescence Ceramide-Based HPLC Assay for Rapidly and Efficiently Assessing Glucosylceramide Synthase In Vivo.Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.Gaucher's disease and cancer: a sphingolipid perspective Glycogen Synthase Kinase 3β Inhibitor (2'Z,3'E)-6-Bromo-indirubin- 3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells.Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.Apoptotic sphingolipid ceramide in cancer therapy.Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells.The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features.Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.A potential daidzein derivative enhances cytotoxicity of epirubicin on human colon adenocarcinoma Caco-2 cells Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster.Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer.Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells.Sphingolipids in colon cancer.Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status ABCB1 and ABCG2 drug transporters are differentially expressed in non-small cell lung cancers (NSCLC) and expression is modified by cisplatin treatment via altered Wnt signaling.Sphingolipids and expression regulation of genes in cancer.Resuscitating wild-type p53 expression by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors.Verotoxin-1 treatment or manipulation of its receptor globotriaosylceramide (gb3) for reversal of multidrug resistance to cancer chemotherapy.Glycans as targets for therapeutic antitumor antibodies.Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer.The network of P-glycoprotein and microRNAs interactions.Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance MRP1 expressed on Burkitt's lymphoma cells was depleted by catfish egg lectin through Gb3-glycosphingolipid and enhanced cytotoxic effect of drugs.3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.Stanniocalcin 2 induces oxaliplatin resistance in colorectal cancer cells by upregulating P-glycoprotein.

P2860

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P2860

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.

http://www.wikidata.org/entity/Q33991690

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

@ast

Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

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type

label

Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

@ast

Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

@en

prefLabel

Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

@ast

Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

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1476-4598-9-145

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Molecular Cancer

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Glucosylceramide synthase upre ...... rc and beta-catenin signaling.

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Gauri A Patwardhan

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Jianxiong Bao

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Kaustubh Bhinge

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Myles C Cabot

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S Michal Jazwinski

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Vineet Gupta

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Yong-Yu Liu

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Yu-Teh Li

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Yunfeng Zhao

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P2860

Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis

Mechanisms of cancer drug resistance

A "silent" polymorphism in the MDR1 gene changes substrate specificity

A vital role for glycosphingolipid synthesis during development and differentiation

In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

Targeting ceramide metabolism--a strategy for overcoming drug resistance.

A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities.

A dual-fluorescence high-throughput cell line system for probing multidrug resistance.

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9

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Harihara M. Mehendale

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44666140

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