Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.
about
Identification of STAT5A and STAT5B target genes in human T cellsHallmarks of glycosylation in cancerEvolving concepts in cancer therapy through targeting sphingolipid metabolismElisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell DeathRe-configuration of sphingolipid metabolism by oncogenic transformation.Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinomaCeramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Doxorubicin, DNA torsion, and chromatin dynamics.Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation.The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells.Resuscitating wild-type p53 expression by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors.Extramedullary disease in plasma cell myeloma: the iceberg phenomenon.Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer.p53 and Ceramide as Collaborators in the Stress ResponseMicrobubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism.p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells.Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.Inhibition of hepatocellular carcinoma growth by blockade of glycosphingolipid synthesis.Sphingolipid metabolism in cancer signalling and therapy.Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.Minority stress and leukocyte gene expression in sexual minority men living with treated HIV infection.Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis.
P2860
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P2860
Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@ast
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@en
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@nl
type
label
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@ast
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@en
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@nl
prefLabel
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@ast
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@en
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@nl
P2093
P2860
P1433
P1476
Suppression of glucosylceramid ...... is in mutant p53 cancer cells.
@en
P2093
Gauri A Patwardhan
Kaustubh Bhinge
S Michal Jazwinski
Vineet Gupta
Yong-Yu Liu
P2860
P304
P356
10.1158/0008-5472.CAN-10-3107
P407
P577
2011-01-28T00:00:00Z