3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme - Wikidata - wikimedia - TriplyDB

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

http://www.wikidata.org/entity/Q33992451

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Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool IMP dehydrogenase: structure, mechanism, and inhibition.The biochemistry of the metabolic poison propionate 3-nitronate and its conjugate acid, 3-nitropropionate Two Defensive Lines in Juvenile Leaf Beetles; Esters of 3-nitropropionic Acid in the Hemolymph and Aposematic Warning Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism.A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II Molecular mechanism of energy conservation in polysulfide respiration Structure of Escherichia coli Succinate:Quinone Oxidoreductase with an Occupied and Empty Quinone-binding Site Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase Perturbation of the Quinone-binding Site of Complex II Alters the Electronic Properties of the Proximal [3Fe-4S] Iron-Sulfur Cluster Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum The Combined Structural and Kinetic Characterization of a Bacterial Nitronate Monooxygenase from Pseudomonas aeruginosa PAO1 Establishes NMO Class I and II Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation Atypical features of Thermus thermophilus succinate:quinone reductase Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola Transmembrane protein alignment and fold recognition based on predicted topology Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state.A split and rearranged nuclear gene encoding the iron-sulfur subunit of mitochondrial succinate dehydrogenase in Euglenozoa.Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins SDHA related tumorigenesis: a new case series and literature review for variant interpretation and pathogenicity.Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast The quinone-binding and catalytic site of complex II.Risk assessment studies on succinate dehydrogenase inhibitors, the new weapons in the battle to control Septoria leaf blotch in wheat.Out of plane distortions of the heme b of Escherichia coli succinate dehydrogenase Vascular and metabolic dysfunction in Alzheimer's disease: a review.A role for human mitochondrial complex II in the production of reactive oxygen species in human skin The quinone binding site in Escherichia coli succinate dehydrogenase is required for electron transfer to the heme b.Investigating the thermostability of succinate: quinone oxidoreductase enzymes by direct electrochemistry at SWNTs-modified electrodes and FTIR spectroscopy Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease Mitochondria: redox metabolism and dysfunction.Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat.Escherichia coli succinate dehydrogenase variant lacking the heme b.Structural basis for malfunction in complex II.Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1 The Alzheimer's disease beta-secretase enzyme, BACE1.Fatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex II

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P2860

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme

http://www.wikidata.org/entity/Q33992451

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2005 nî lūn-bûn

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2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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3-nitropropionic acid is a sui ...... the active site of the enzyme

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Journal of Biological Chemistry

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3-nitropropionic acid is a sui ...... the active site of the enzyme

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P2093

Andy C Wang

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David Cobessi

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Edward A Berry

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Eric Y Tung

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Gang Sun

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John T Shen

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Li-shar Huang

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Vernon E Anderson

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P2860

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural and mechanistic mapping of a unique fumarate reductase

Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution

Identification of the active site acid/base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study

A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction

Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site

Architecture of succinate dehydrogenase and reactive oxygen species generation

SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

The CCP4 suite: programs for protein crystallography

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5965-5972

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scholarly article

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10.1074/JBC.M511270200

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9

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281

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2005-12-21T00:00:00Z

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16371358

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veteran suicide

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1482830

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