IMP dehydrogenase: structure, mechanism, and inhibition. - Wikidata - wikimedia - TriplyDB

IMP dehydrogenase: structure, mechanism, and inhibition.

IMP dehydrogenase: structure, mechanism, and inhibition.

http://www.wikidata.org/entity/Q24642299

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Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans The AEROPATH project targetingPseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery Structure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenase Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase Increased riboflavin production by manipulation of inosine 5'-monophosphate dehydrogenase in Ashbya gossypii Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Undercover: gene control by metabolites and metabolic enzymes A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis Suppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors.Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals Identification and Functional Analysis of the Mycophenolic Acid Gene Cluster of Penicillium roqueforti Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors Comprehensive analysis of type 1 fimbriae regulation in fimB-null strains from the multidrug resistant Escherichia coli ST131 clone.Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesis Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.Inosine monophosphate dehydrogenase expression and activity are significantly lower in kidney transplant recipients with diabetes mellitus.A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus.Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors.A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixture A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.In silico design of human IMPDH inhibitors using pharmacophore mapping and molecular docking approaches Kinetically controlled drug resistance: how Penicillium brevicompactum survives mycophenolic acid Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster Adaptive evolution of drug targets in producer and non-producer organisms.New X-chromosomal interactors of dFMRP regulate axonal and synaptic morphology of brain neurons in Drosophila melanogaster

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P2860

IMP dehydrogenase: structure, mechanism, and inhibition.

http://www.wikidata.org/entity/Q24642299

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

IMP dehydrogenase: structure, mechanism, and inhibition

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IMP dehydrogenase: structure, mechanism, and inhibition.

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IMP dehydrogenase: structure, mechanism, and inhibition.

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type

label

IMP dehydrogenase: structure, mechanism, and inhibition

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IMP dehydrogenase: structure, mechanism, and inhibition.

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IMP dehydrogenase: structure, mechanism, and inhibition.

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prefLabel

IMP dehydrogenase: structure, mechanism, and inhibition

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IMP dehydrogenase: structure, mechanism, and inhibition.

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IMP dehydrogenase: structure, mechanism, and inhibition.

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Chemical Reviews

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IMP dehydrogenase: structure, mechanism, and inhibition.

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Lizbeth Hedstrom

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P2860

An enzymatic atavist revealed in dual pathways for water activation

Genomic Minimalism in the Early Diverging Intestinal Parasite Giardia lamblia

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo

Inosine 5'-phosphate dehydrogenase of pea seeds

Autosomal dominant retinitis pigmentosa mutations in inosine 5'-monophosphate dehydrogenase type I disrupt nucleic acid binding

RNA virus error catastrophe: direct molecular test by using ribavirin

Bateman domains and adenosine derivatives form a binding contract

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration?

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2903-2928

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scholarly article

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2198921

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10.1021/CR900021W

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19480389

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