Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori
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Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pyloriEnzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori.Identification of a Mycobacterium tuberculosis putative classical nitroreductase gene whose expression is coregulated with that of the acr aene within macrophages, in standing versus shaking cultures, and under low oxygen conditions.Response to metronidazole and oxidative stress is mediated through homeostatic regulator HsrA (HP1043) in Helicobacter pylori.Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori.Flavodoxin:quinone reductase (FqrB): a redox partner of pyruvate:ferredoxin oxidoreductase that reversibly couples pyruvate oxidation to NADPH production in Helicobacter pylori and Campylobacter jejuni.Accurate, noninvasive detection of Helicobacter pylori DNA from stool samples: potential usefulness for monitoring treatment.Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistanceAdherence and invasion of mouse-adapted H pylori in different epithelial cell lines.Characterisation of the genes encoding resistance to metronidazole (rdxA and frxA) and clarithromycin (the 23S-rRNA genes) in South African isolates of Helicobacter pylori.DNA sequence analysis of rdxA and frxA from 12 pairs of metronidazole-sensitive and -resistant clinical Helicobacter pylori isolates.Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole.CagA status & genetic characterization of metronidazole resistant strains of H. pylori from: A region at high risk of gastric cancerAnalysis of clinical isolates of Helicobacter pylori in Pakistan reveals high degrees of pathogenicity and high frequencies of antibiotic resistance.Validation of string test for diagnosis of Helicobacter pylori infections.Molecular testing for antibiotic resistance in Helicobacter pylori.Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolateChange is good: variations in common biological mechanisms in the epsilonproteobacterial genera Campylobacter and HelicobacterVirulence genes and neutral DNA markers of Helicobacter pylori isolates from different ethnic communities of West Bengal, India.Review article: Deoxyribonucleic acid-based diagnostic techniques to detect Helicobacter pylori.Molecular biology methods for the characterization of Helicobacter pylori infections and their diagnosis.Clarithromycin-Based Triple Therapy is Still Useful as an Initial Treatment for Helicobacter pylori Infection in the Dominican Republic.Stability of randomly amplified polymorphic DNA fingerprinting in genotyping clinical isolates of Helicobacter pylori.Antimicrobial susceptibility and resistance patterns among Helicobacter pylori strains from The Gambia, West Africa.The membrane as a target for controlling hypervirulent Clostridium difficile infections.Proteomic analysis of a NAP1 Clostridium difficile clinical isolate resistant to metronidazole.Universal high-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt.Antimicrobial susceptibility of Helicobacter pylori strains isolated in BangladeshNovel Helicobacter pylori therapeutic targets: the unusual suspects.The mutation of the rdxA gene in metronidazole-resistant Helicobacter pylori clinical isolates.Helicobacter pylori and Antibiotic Resistance, A Continuing and Intractable Problem.Julian Davies and the discovery of kanamycin resistance transposon Tn5.Differentiation of metronidazole-sensitive and -resistant clinical isolates of Helicobacter pylori by immunoblotting with antisera to the RdxA protein.Spontaneous mutations that confer antibiotic resistance in Helicobacter pylori.Metronidazole activation is mutagenic and causes DNA fragmentation in Helicobacter pylori and in Escherichia coli containing a cloned H. pylori RdxA(+) (Nitroreductase) gene.Mouse-colonizing Helicobacter pylori SS1 is unusually susceptible to metronidazole due to two complementary reductase activities.Emergence of tetracycline resistance in Helicobacter pylori: multiple mutational changes in 16S ribosomal DNA and other genetic loci.Molecular patchwork: Chromosomal recombination between two Helicobacter pylori strains during natural colonization.The fdxA ferredoxin gene can down-regulate frxA nitroreductase gene expression and is essential in many strains of Helicobacter pylori.Motility of urease-deficient derivatives of Helicobacter pylori.
P2860
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P2860
Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@ast
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@en
type
label
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@ast
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@en
prefLabel
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@ast
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@en
P2093
P2860
P1476
Sequential inactivation of rdx ...... istance in Helicobacter pylori
@en
P2093
A J Parkinson
A K Mukhopadhyay
B Velapatiño
D Dailidiene
D Kersulyte
P2860
P304
P356
10.1128/JB.182.18.5082-5090.2000
P407
P577
2000-09-01T00:00:00Z