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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk Oxidative Stress in Neurodegenerative Diseases Molecular motor proteins and amyotrophic lateral sclerosis Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Redox regulation in amyotrophic lateral sclerosis Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS The Cu, Zn Superoxide Dismutase: Not Only a Dismutase Enzyme Emerging mechanisms of molecular pathology in ALS Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: a phase I pilot study Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis Solid-state NMR studies of metal-free SOD1 fibrillar structures.Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.Cutting off functional loops from homodimeric enzyme superoxide dismutase 1 (SOD1) leaves monomeric β-barrels.A random set scoring model for prioritization of disease candidate genes using protein complexes and data-mining of GeneRIF, OMIM and PubMed records.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Sex-dependent effects of chromogranin B P413L allelic variant as disease modifier in amyotrophic lateral sclerosis Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis.Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot.Cu, Zn-superoxide dismutase 1 (SOD1) is a novel target of Puromycin-sensitive aminopeptidase (PSA/NPEPPS): PSA/NPEPPS is a possible modifier of amyotrophic lateral sclerosis.Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients.Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.Repetitive nerve stimulation transiently opens the mitochondrial permeability transition pore in motor nerve terminals of symptomatic mutant SOD1 mice The carbonylation and covalent dimerization of human superoxide dismutase 1 caused by its bicarbonate-dependent peroxidase activity is inhibited by the radical scavenger tempol.Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis.Altered intracellular localization of SOD1 in leukocytes from patients with sporadic amyotrophic lateral sclerosis.Proteins that bind to misfolded mutant superoxide dismutase-1 in spinal cords from transgenic amyotrophic lateral sclerosis (ALS) model mice.Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral sclerosis.Genotype-property patient-phenotype relations suggest that proteome exhaustion can cause amyotrophic lateral sclerosis.Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

http://www.wikidata.org/entity/Q33996210

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

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type

label

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

@ast

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

@en

prefLabel

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

@ast

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

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JOURNAL.PONE.0011552

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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

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Daniel Bergemalm

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Johan Jacobsson

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Karin Forsberg

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Karin S Graffmo

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Magnus Hultdin

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P Andreas Jonsson

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Roland Rosquist

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Stefan L Marklund

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Thomas Brännström

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P2860

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Extracellular superoxide dismutase in human tissues and human cell lines

Misfolded CuZnSOD and amyotrophic lateral sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Unraveling the mechanisms involved in motor neuron degeneration in ALS

Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants

Gait analysis detects early changes in transgenic SOD1(G93A) mice

New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes.

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e11552

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scholarly article

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10.1371/JOURNAL.PONE.0011552

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7

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Peter M Andersen

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2010-07-14T00:00:00Z

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45275887

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20644736

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amyotrophic lateral sclerosis

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2904380

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