Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis.
about
Identification of host cell factors required for intoxication through use of modified cholera toxinCholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities.Transfer of the cholera toxin A1 polypeptide from the endoplasmic reticulum to the cytosol is a rapid process facilitated by the endoplasmic reticulum-associated degradation pathwayInhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin.ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide.The cholera toxin A1(3) subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosolStructural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidisCholera holotoxin assembly requires a hydrophobic domain at the A-B5 interface: mutational analysis and development of an in vitro assembly system.A mutational analysis of residues in cholera toxin A1 necessary for interaction with its substrate, the stimulatory G protein Gsα.Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signalingVesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein.Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilisDesign and in silico screening of inhibitors of the cholera toxin.Structural inferences for Cholera toxin mutations in Vibrio cholerae.
P2860
Q30467347-1E3F7662-28A2-420B-8E2A-799D9039A194Q30775971-DA5CAF1A-9DF8-4E8D-AE65-0C353AFFE735Q33978346-C3D88848-7A63-4199-89C6-12048550D4F0Q34186016-3C779B34-AF15-49D0-8413-2D1300816CC0Q34186098-2468ED7A-7145-464F-8B63-CF288F5FCDA2Q34490469-83949291-FDC8-4D56-AA61-610EFC6401F0Q34492828-B18104BA-96A6-457A-88E7-CB9A51E41AEFQ34868826-2811A208-C735-4E76-AA44-C3B15467E866Q35106484-4C3FA34B-F6C4-4ADB-B092-A2B9482C4B81Q35232732-6D5932A2-4965-4452-933D-93422BFC23FCQ35750997-9203F462-0EA3-4300-8617-E4838F37A079Q36539596-44F5EE1A-727F-4BC1-8F94-5376A9D3C41AQ37154230-3B9C445A-B1E1-4E40-9F50-439EA9EE633CQ37623472-529FBB4A-CF5B-4766-8761-4C3497DA5CE2Q37623929-D145D5AC-CD7C-4D2C-AAF3-01CDDD24D3E5Q38088362-46A52D8C-4AFE-49BE-A357-264C89D598FAQ41865473-435DB252-2B29-4E04-9554-CF984A703F2E
P2860
Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Biological and biochemical cha ...... by site-directed mutagenesis.
@ast
Biological and biochemical cha ...... by site-directed mutagenesis.
@en
type
label
Biological and biochemical cha ...... by site-directed mutagenesis.
@ast
Biological and biochemical cha ...... by site-directed mutagenesis.
@en
prefLabel
Biological and biochemical cha ...... by site-directed mutagenesis.
@ast
Biological and biochemical cha ...... by site-directed mutagenesis.
@en
P2860
P1476
Biological and biochemical cha ...... by site-directed mutagenesis.
@en
P2093
M G Jobling
R K Holmes
P2860
P304
P356
10.1128/JB.183.13.4024-4032.2001
P407
P577
2001-07-01T00:00:00Z