Transfer of the cholera toxin A1 polypeptide from the endoplasmic reticulum to the cytosol is a rapid process facilitated by the endoplasmic reticulum-associated degradation pathway
about
The pertussis toxin S1 subunit is a thermally unstable protein susceptible to degradation by the 20S proteasomeRicin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 {degrees}CThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyA therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunitStabilization of the tertiary structure of the cholera toxin A1 subunit inhibits toxin dislocation and cellular intoxicationDetection of toxin translocation into the host cytosol by surface plasmon resonance.Identification of host cell factors required for intoxication through use of modified cholera toxinHsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.Inhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin.The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effectContribution of subdomain structure to the thermal stability of the cholera toxin A1 subunit.Toxin instability and its role in toxin translocation from the endoplasmic reticulum to the cytosol.The cholera toxin A1(3) subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosolProtein-disulfide isomerase displaces the cholera toxin A1 subunit from the holotoxin without unfolding the A1 subunitCharacterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.Map-based comparative genomic analysis of virulent haemophilus parasuis serovars 4 and 5.Structural and functional interactions between the cholera toxin A1 subunit and ERdj3/HEDJ, a chaperone of the endoplasmic reticulum.Inhibition of Cholera Toxin and Other AB Toxins by Polyphenolic Compounds.Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases.Order-disorder-order transitions mediate the activation of cholera toxin.CD4 and BST-2/tetherin proteins retro-translocate from endoplasmic reticulum to cytosol as partially folded and multimeric molecules.Vesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein.Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.Differential activities of plant polyphenols on the binding and internalization of cholera toxin in vero cells.Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.A component of the Sec61 ER protein transporting pore is required for plant susceptibility to powdery mildew.Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation.Conformational instability of the cholera toxin A1 polypeptideA novel mode of translocation for cytolethal distending toxin.Engineering an AB Protein Carrier
P2860
Q24642842-16606B76-08A7-46F2-A2D5-94437E4E5F70Q24647411-479E9951-4F2C-4EF2-B555-EEB45680D760Q27015793-F9AB51C7-FB8B-4F35-84EA-26C4980C2AFBQ28477818-6107A652-84B9-4D6B-8A74-AC6775788B8DQ28485727-AEDFCB95-8AB3-436D-BBFF-AEC6856CAEB0Q30455169-9C5BDD96-184D-4B2D-B2AE-C1C04DA43356Q30467347-FF29CC15-83C5-47B2-BE25-3D2A362C7F53Q34181280-F2E6961B-BFFA-4879-BC9F-EA70A6AD8146Q34186098-E53F551F-B143-4583-B771-EAF98077A9D3Q34407346-79B11452-AD10-4A0C-B91B-62262DF21103Q34412913-85166375-FCB1-4EAE-8058-594D24938570Q34426721-D624B4DE-3173-4064-8C30-BA02AC39F64BQ34492828-61D63055-3481-4871-B7A9-DD8CB63BEBFAQ35063023-132EDCCD-D7A9-4900-A622-EE57F1B1B181Q35066293-979DACC1-4D39-46BF-943C-FE3E9D0E1749Q35601341-8537AB81-7FCC-4CA4-86AD-7DCC73F2B6A4Q35671627-4B3F8921-FB80-4E78-867C-D50955161697Q36187443-32A98044-CCF5-447E-96CD-27C80D51F0E1Q36217769-305AC132-F276-4083-98AB-7B9876DA6698Q36739680-0A7F7678-F312-4546-BC50-37B24568F595Q37428581-34EA3077-B8D9-41C8-93F6-F6210C84AFC8Q37623472-EB9E44F2-D25C-48AF-85A0-87913F1FBF7BQ37954281-EECEE110-05DB-45B0-B17E-4F6A09FBB611Q38328355-04CC22D3-793D-46EF-8AF0-5135B4EE8193Q40286860-61B730C4-98AA-466C-8956-D8807E82FAF6Q40747446-1D50B0D5-3725-4312-B9DD-336BEA0DDB17Q41832901-AC75BE1A-BD83-40CD-85D3-7DBDC72757CDQ41835060-5BFD1ED9-C70A-47D2-B642-2F4B37399086Q42102805-35F34C05-A412-411C-8F82-10CAB78DFC5FQ58714293-2197D5AF-9DB3-49F7-9214-0427BABAADDE
P2860
Transfer of the cholera toxin A1 polypeptide from the endoplasmic reticulum to the cytosol is a rapid process facilitated by the endoplasmic reticulum-associated degradation pathway
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Transfer of the cholera toxin ...... associated degradation pathway
@ast
Transfer of the cholera toxin ...... associated degradation pathway
@en
Transfer of the cholera toxin ...... associated degradation pathway
@nl
type
label
Transfer of the cholera toxin ...... associated degradation pathway
@ast
Transfer of the cholera toxin ...... associated degradation pathway
@en
Transfer of the cholera toxin ...... associated degradation pathway
@nl
prefLabel
Transfer of the cholera toxin ...... associated degradation pathway
@ast
Transfer of the cholera toxin ...... associated degradation pathway
@en
Transfer of the cholera toxin ...... associated degradation pathway
@nl
P2093
P2860
P1476
Transfer of the cholera toxin ...... associated degradation pathway
@en
P2093
Randall K Holmes
Rebecca L Allyn
P2860
P304
P356
10.1128/IAI.70.11.6166-6171.2002
P407
P577
2002-11-01T00:00:00Z