MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.
about
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblastsActivation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damageDevelopmental context determines latency of MYC-induced tumorigenesisInhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genesMechanisms of apoptosis by c-Myc.A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Ladder-like amplification of the type I interferon gene cluster in the human osteosarcoma cell line MG63An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma.The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletionProfiling breast cancer by array CGH.Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.Neoplastic transformation of human small airway epithelial cells induced by arsenic.Mitochondrial alteration in malignantly transformed human small airway epithelial cells induced by α-particlesTransient excess of MYC activity can elicit genomic instability and tumorigenesis.A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides.c-MYC overexpression in Ba/F3 cells simultaneously elicits genomic instability and apoptosis.Genome position and gene amplificationRegulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.Limited role of N-terminal phosphoserine residues in the activation of transcription by p53.Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation.The p53 network.c-MYC-induced genomic instability.Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation.Shaping of tumor and drug-resistant genomes by instability and selection.
P2860
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P2860
MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@ast
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@en
type
label
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@ast
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@en
prefLabel
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@ast
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@en
P2093
P2860
P356
P1476
MYC abrogates p53-mediated cel ...... itting CAD gene amplification.
@en
P2093
M L Agarwal
M V Chernov
O B Chernova
Y Ishizaka
P2860
P304
P356
10.1128/MCB.18.1.536
P407
P577
1998-01-01T00:00:00Z