Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins LT-IIa and LT-IIb
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Immune Adjuvant Effect of Molecularly-defined Toll-Like Receptor LigandsMucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities.Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins.Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins.Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells.Enhanced antigen uptake by dendritic cells induced by the B pentamer of the type II heat-labile enterotoxin LT-IIa requires engagement of TLR2.Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I)Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent costimulation of CD4(+) T cells.LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb.Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigenImmunization for protection of the reproductive tract: a review.Dental caries vaccines: prospects and concerns.Characterization of antigen-presenting cells induced by intragastric immunization with recombinant chimeric immunogens constructed from Streptococcus mutans AgI/II and type I or type II heat-labile enterotoxinsPlasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines.Distinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration.TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin.Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants.In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesisComparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: applications for oral infections.Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal ColonizationLT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunityIn vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli.Heat-labile enterotoxins as adjuvants or anti-inflammatory agents.Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract.Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40 ligand on CD4(+) T cells.The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia.Colonization of gnotobiotic mice with human gut microflora at birth protects against Escherichia coli heat-labile enterotoxin-mediated abrogation of oral tolerance.
P2860
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P2860
Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins LT-IIa and LT-IIb
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2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@ast
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@en
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@nl
type
label
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@ast
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@en
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@nl
prefLabel
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@ast
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@en
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@nl
P2093
P2860
P1476
Comparative analysis of the mu ...... enterotoxins LT-IIa and LT-IIb
@en
P2093
D J Metzger
S M Michalek
T D Connell
P2860
P304
P356
10.1128/IAI.68.1.281-287.2000
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P577
2000-01-01T00:00:00Z