Null mutations in human and mouse orthologs frequently result in different phenotypes.
about
Testing the ortholog conjecture with comparative functional genomic data from mammalsDrug target prediction and prioritization: using orthology to predict essentiality in parasite genomesFrom mouse to human: evolutionary genomics analysis of human orthologs of essential genesIntegrative annotation of variants from 1092 humans: application to cancer genomicsThe methodological quality of animal research in critical care: the public face of scienceMouse genetic and phenotypic resources for human geneticsDEG 5.0, a database of essential genes in both prokaryotes and eukaryotesDefining the role of essential genes in human diseaseThe PsychENCODE projectNew genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovationMyeloperoxidase: a front-line defender against phagocytosed microorganismsDEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elementsAn Ancient Evolutionary Origin of Genes Associated with Human Genetic DiseasesA general framework for estimating the relative pathogenicity of human genetic variantsA manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology.The ortholog conjecture is untestable by the current gene ontology but is supported by RNA sequencing data.Effect of duplicate genes on mouse genetic robustness: an update.Moss and liverwort xyloglucans contain galacturonic acid and are structurally distinct from the xyloglucans synthesized by hornworts and vascular plants.An evolutionary and structural characterization of mammalian protein complex organization.Why is the correlation between gene importance and gene evolutionary rate so weak?A tree shrew glioblastoma model recapitulates features of human glioblastomaThe use of orthologous sequences to predict the impact of amino acid substitutions on protein function.The biological context of HIV-1 host interactions reveals subtle insights into a system hijackA yeast's eye view of mammalian reproduction: cross-species gene co-expression in meiotic prophase.Comparison of computational models for assessing conservation of gene expression across species.A simple meningococcal sepsis prognostic score: focusing on the human animalWhy human disease-associated residues appear as the wild-type in other species: genome-scale structural evidence for the compensation hypothesis.Contrasting genetic paths to morphological and physiological evolution.The Mouse Lemur, a Genetic Model Organism for Primate Biology, Behavior, and Health.Biological interaction networks are conserved at the module levelGene family size conservation is a good indicator of evolutionary rates.Ortho2ExpressMatrix--a web server that interprets cross-species gene expression data by gene family informationHealth and population effects of rare gene knockouts in adult humans with related parentsMamPhEA: a web tool for mammalian phenotype enrichment analysis.Modes of gene duplication contribute differently to genetic novelty and redundancy, but show parallels across divergent angiosperms.Molecular foundations of reproductive lethality in Arabidopsis thaliana.Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic dataHighly Specific Modulators of Protein Kinase C Localization: Applications to Heart FailureComparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans.Interpretation of genomic variants using a unified biological network approach.
P2860
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P2860
Null mutations in human and mouse orthologs frequently result in different phenotypes.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@ast
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@en
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@nl
type
label
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@ast
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@en
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@nl
prefLabel
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@ast
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@en
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@nl
P2860
P356
P1476
Null mutations in human and mouse orthologs frequently result in different phenotypes.
@en
P2093
Ben-Yang Liao
Jianzhi Zhang
P2860
P304
P356
10.1073/PNAS.0800387105
P407
P577
2008-05-05T00:00:00Z