A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo. - Wikidata - wikimedia - TriplyDB

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

http://www.wikidata.org/entity/Q34030874

about

Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal models Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity Reducing synuclein accumulation improves neuronal survival after spinal cord injury Molecular Tweezers Targeting Transthyretin Amyloidosis Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03 Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.Binding cavities and druggability of intrinsically disordered proteins.Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity.Targeting intrinsically disordered proteins in rational drug discovery.A molecular tweezer antagonizes seminal amyloids and HIV infection.Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules.Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model.Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease.Intrinsically disordered proteins and novel strategies for drug discovery.α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease.A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.Supramolecular Chemistry Targeting Proteins.Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation Alpha-synuclein oligomers: a new hope.Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.Alpha-synuclein, proteotoxicity and Parkinson's disease: Search for neuroprotective therapy.LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation.Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.

P2860

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P2860

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

http://www.wikidata.org/entity/Q34030874

description

2012 nî lūn-bûn

@nan

2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

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2012年论文

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name

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@ast

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@en

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@nl

type

label

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@ast

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@en

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@nl

prefLabel

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@ast

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@en

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

@nl

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S13311-012-0105-1

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Neurotherapeutics

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A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo

@en

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Aida Attar

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Arthur G Fitzmaurice

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Aswani Kotagiri

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Frank-Gerrit Klärner

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Gal Bitan

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Jeff M Bronstein

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Joseph A Loo

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Magdalena I Ivanova

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Rajeswari Lakshmanan

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Shubhangi Prabhudesai

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P2860

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Alpha-synuclein in Lewy bodies

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Impairment of the ubiquitin-proteasome system by protein aggregation

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity.

The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum).

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10.1007/S13311-012-0105-1

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2

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9

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Sharmistha Sinha

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2012-04-01T00:00:00Z

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221869674

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