Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
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Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsIntraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.Anodal transcranial direct current stimulation boosts synaptic plasticity and memory in mice via epigenetic regulation of Bdnf expression.Reducing synuclein accumulation improves neuronal survival after spinal cord injuryMolecular Tweezers Targeting Transthyretin AmyloidosisNeurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish EmbryosAmyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.An overview of drugs currently under investigation for the treatment of transthyretin-related hereditary amyloidosis.Structure and mechanism of action of tau aggregation inhibitors.A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease.Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.A molecular tweezer antagonizes seminal amyloids and HIV infection.Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulationTau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium.A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42Supramolecular Chemistry Targeting Proteins.Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregationMetabolic and Growth Rate Alterations in Lymphoblastic Cell Lines Discriminate Between Down Syndrome and Alzheimer's Disease.Alpha-synuclein oligomers: a new hope.Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons.
P2860
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P2860
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
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2012年學術文章
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name
Protection of primary neurons ...... thology by molecular tweezers.
@ast
Protection of primary neurons ...... thology by molecular tweezers.
@en
type
label
Protection of primary neurons ...... thology by molecular tweezers.
@ast
Protection of primary neurons ...... thology by molecular tweezers.
@en
prefLabel
Protection of primary neurons ...... thology by molecular tweezers.
@ast
Protection of primary neurons ...... thology by molecular tweezers.
@en
P2093
P2860
P50
P356
P1433
P1476
Protection of primary neurons ...... thology by molecular tweezers.
@en
P2093
Aida Attar
Chi-Hong Tseng
Cui-Wei Xie
Elisa Riccardi
Frank-Gerrit Klärner
Fusheng Yang
Greg D Gale
Jane Hayes
Jeffrey L Straudinger
P2860
P304
P356
10.1093/BRAIN/AWS289
P407
P577
2012-11-26T00:00:00Z