Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior. - Wikidata - wikimedia - TriplyDB

Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.

Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.

http://www.wikidata.org/entity/Q34035211

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Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear.Discovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL.The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline.Translational Research on Nicotine Dependence.Contributions of β2 subunit-containing nAChRs to chronic nicotine-induced alterations in cognitive flexibility in mice.Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression Anxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptors Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile Nicotinic receptor contributions to smoking: insights from human studies and animal models Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo The antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain models Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice.Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo.Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP).Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawal.Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability.Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors.Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings.Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.Nicotine Addiction and Psychiatric Disorders.The (α4)3(β2)2 Stoichiometry of the Nicotinic Acetylcholine Receptor Predominates in the Rat Motor Cortex.Substance use modulates stress reactivity: Behavioral and physiological outcomes.Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's Disease Acute activation, desensitization and smoldering activation of human acetylcholine receptors.Distinct Roles of CREB Within the Ventral and Dorsal Hippocampus in Mediating Nicotine Withdrawal Phenotypes.TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors.Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect.

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P2860

Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.

http://www.wikidata.org/entity/Q34035211

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Nicotinic partial agonists var ...... effects on affective behavior.

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Journal of Pharmacology and Experimental Therapeutics

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Nicotinic partial agonists var ...... effects on affective behavior

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Julie A Blendy

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Laura M Castellano

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P2860

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors

The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid

Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications

Varenicline improves mood and cognition during smoking abstinence.

Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice

Anxiolytic effects of nicotine in a rodent test of approach-avoidance conflict.

Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.

Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors.

Effect of nicotine and nicotinic receptors on anxiety and depression.

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