Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.
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Attention-modulating effects of cognitive enhancersChemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depressionNicotine receptors and depression: revisiting and revising the cholinergic hypothesisAntagonists show GTP-sensitive high-affinity binding to the sigma-1 receptorDesensitization of nicotinic acetylcholine receptors as a strategy for drug development.Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking CessationEnantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.Nicotinic receptor modulation to treat alcohol and drug dependenceLow dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in miceQuantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampusDissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear.Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophreniaEffects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.Nicotinic partial agonists varenicline and sazetidine-A have differential effects on affective behavior.The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.Nicotinic receptor antagonists as treatments for nicotine abuse.Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline.Structural answers and persistent questions about how nicotinic receptors work.Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal.Animal models to assess the abuse liability of tobacco products: effects of smokeless tobacco extracts on intracranial self-stimulation.Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferentsAn autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutantsα6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depressionTwo novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profileVarenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivoPKCε phosphorylates α4β2 nicotinic ACh receptors and promotes recovery from desensitizationThe antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain modelsAssessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female ratsSazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo.Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the MouseDifferential α4(+)/(-)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms.
P2860
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P2860
Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@ast
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@en
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@nl
type
label
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@ast
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@en
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@nl
prefLabel
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@ast
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@en
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@nl
P2093
P356
P1476
Sazetidine-A, a novel ligand t ...... ptors without activating them.
@en
P2093
Alan P Kozikowski
John L Musachio
Kenneth J Kellar
Sheela K Chellappan
Yingxian Xiao
Zhi-Liang Wei
P304
P356
10.1124/MOL.106.027318
P577
2006-07-20T00:00:00Z