The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
about
The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal CancerPharmacodynamic Biomarker Development for PI3K Pathway TherapeuticsPI3K and AKT: Unfaithful Partners in CancerConcomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.Sustained proliferation in cancer: Mechanisms and novel therapeutic targetsGenotype directed therapy in murine mismatch repair deficient tumorsRecent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical developmentEffective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways.Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal cancers independent of KRAS mutational status.MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma.Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells.Genetically engineered mouse models of PI3K signaling in breast cancer.NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation.Cell specific apoptosis by RLX is mediated by NFκB in human colon carcinoma HCT-116 cells.AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axisPUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancerTreatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell PopulationBlockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells.Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.mTOR pathway in colorectal cancer: an update.Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions.The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance.Targeting mTOR network in colorectal cancer therapyPI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.The promise of mTOR inhibitors in the treatment of colorectal cancer.Targeting PI3K in Cancer: Any Good News?Targeting the mTOR signaling network for Alzheimer's disease therapy.Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitationsTargeting PI3Kδ: emerging therapy for chronic lymphocytic leukemia and beyond.In vivo genome editing and organoid transplantation models of colorectal cancer and metastasisDesign, Synthesis, Activity and Docking Study of Sorafenib Analogs Bearing Sulfonylurea Unit.Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress.Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/mTOR dual inhibitor BEZ235 through apoptosis.PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells.PTRF suppresses the progression of colorectal cancers.Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
P2860
Q26744721-0491873B-DCC4-4B1A-B0B9-0D447B5606C6Q26766292-296A455F-3F4E-4291-A411-A7A1EA5170EAQ26781367-49576C69-8B86-47AA-92FD-809BBA48E9AEQ27852136-013AF8E8-F45B-4FE0-853D-9B0DFC5B1BACQ28396388-C12AFDD4-A241-46DB-98B7-273DEB726A95Q28534803-EDE4FC33-DFEB-4CC0-A347-1D6A52A92CABQ33776641-20E253A4-03CF-4413-B765-FC85B70CCCD3Q33934922-CE9EDA60-BF3D-48DE-9F79-51E554EA99FBQ33999493-174B0B87-4EF1-49E9-A1A3-EDF330911D1BQ34182679-F73D543A-5416-4B40-8394-481D162D56D9Q34188530-2B72B0D1-BFFB-467D-B86A-75274DEB7683Q34332175-9A3933BA-B52F-4BF9-93B9-C0DA0C307D56Q34679652-4DC375C3-D822-4F9B-95DC-2ABB93E5B2D6Q35063769-99346B13-4526-428C-9926-E3C0D20AB94DQ35321647-F7EA9745-67AB-4E90-B5F8-A2FD6192042CQ35987253-070024C7-A92C-4292-8035-E711C945284EQ35987363-65FA7BBB-21AE-482F-BFE6-991B694019CBQ36471425-E8A1FE70-AB72-4D20-91C7-FDF9EEA2332FQ36985432-A25C01DB-E186-4D8B-883E-367B36E12694Q37632641-5359F01F-8CD4-4C77-ABCC-CDAF2D0B3EA7Q37649634-55894398-9B7A-43B6-9608-84B658C4A722Q37660260-5133B345-1C36-4072-9832-CEA5F7A5CD7FQ37687348-FABB4583-B137-4986-8B27-81B5066B634BQ37708005-437DE171-A82C-453F-BA37-5A541D5E82DBQ37727180-2B608059-6088-4BCE-B593-FB62D50FABF2Q38042938-3201BC6A-4126-42EA-AA80-DBF2F954888AQ38043507-F4F0299B-D018-4C52-ADB8-989B17426260Q38105322-D77C3EEB-B28D-4588-B753-1207F66A5168Q38121524-CA470BF1-C8F0-4939-8A40-F47E75E62D15Q38208069-EB65E117-2708-4325-8C97-A95C88E61FFBQ38375141-7F7ABB4D-1AB6-424F-B6C9-418E4098EB4FQ38705367-10EE2033-A8AA-490A-8EA7-6BBF85503290Q38824026-0B292628-9FB0-40F3-8E66-C9EFBEBCD553Q38946538-0B9A86B9-D18A-45A0-A110-8931787D2837Q39067602-2A5B83AB-0E9F-4F6A-8ABF-A3A843893547Q39255433-ED085140-C46A-40E0-8169-315C0713FC24Q39735209-89D77F55-01B2-440C-8DCB-C2588459E62CQ40509393-1673BABB-3D0E-4570-96F3-8CBE4B7B8910Q41472038-DDFBE537-3C75-47E1-9B75-EC088A837E29Q42085487-9E2E277E-393C-474E-91F2-2B2B295E78E5
P2860
The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@ast
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@en
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@nl
type
label
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@ast
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@en
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@nl
prefLabel
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@ast
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@en
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@nl
P2093
P2860
P1433
P1476
The dual PI3K/mTOR inhibitor N ...... A wild-type colorectal cancer.
@en
P2093
Eric S Martin
Erin M Coffee
Kenneth E Hung
Larissa Georgeon Richard
Mark J Sinnamon
Michael P Richardson
Peng-Chieh Chen
Roderick T Bronson
P2860
P304
P356
10.1371/JOURNAL.PONE.0025132
P407
P50
P577
2011-09-26T00:00:00Z