Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice - Wikidata - wikimedia - TriplyDB

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

http://www.wikidata.org/entity/Q34045591

about

Acute systemic DNA damage in youth does not impair immune defense with aging Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells Building for the future: essential infrastructure for rodent ageing studies DNA Damage Response in Hematopoietic Stem Cell Ageing "Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules Senescent intimal foam cells are deleterious at all stages of atherosclerosis Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells Senescence associated macrophages and "macroph-aging": are they pieces of the same puzzle?Oncogenic senescence: a multi-functional perspective.A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC.Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.Senotherapy: growing old and staying young?Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans.Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.Context-dependent effects of cellular senescence in cancer development.The Aging Epigenome Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis.Ageing and the pathogenesis of osteoarthritis.Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases.Elimination of p19(ARF)-expressing cells enhances pulmonary function in mice.Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function.Robust, universal biomarker assay to detect senescent cells in biological specimens.Conserved and novel functions of programmed cellular senescence during vertebrate development.Cellular senescence in osteoarthritis pathology.Disease drivers of aging.Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging.New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 Quantitative Analysis of Cellular Senescence in Culture and In Vivo.Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.Oxidative stress in mesenchymal stem cell senescence: regulation by coding and non-coding RNAs.p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.Bcl-2 proteins in development, health, and disease of the hematopoietic system.Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway.Renal Aging: Causes and Consequences.

P2860

Q26700113-9B692676-A865-4F72-9D3E-E2EEAF3BFD2F Q26740026-98F49011-08EA-4C04-AC36-833FB6F84B05 Q26746090-B13D108D-40BE-4EAB-A883-B8ABF7F490EE Q26746094-1B24A6B1-9665-46CA-B0BF-AEDB531FDBE9 Q26747251-91F18487-B2D2-4D30-AE86-0A1B34925976 Q26747742-00A17E3D-19ED-4F7B-AA18-FAA6B878C0FF Q28595661-3D71EFF9-1F5C-4430-ADBB-9F5D039E0BCC Q28972229-98C10EAC-6708-484F-B27F-AC71684E1146 Q33364422-35B73E92-BDBC-459A-8925-B9C21DB08490 Q33689160-DEF6D4DE-0200-43B2-B062-7B0C05AE0BF3 Q33689457-12BCE06A-104B-4A54-BD64-2F58C1228DCE Q34045737-0F1716E6-1E88-44C9-AE2F-586A0AB2B905 Q34046604-DF249307-63B1-4D7B-AF01-7EDBFFC24971 Q34547450-05107221-0E19-4E80-944F-714173B55EE9 Q34681446-401F1DFA-0322-401E-8919-B2EF20817C20 Q36204662-2A6E02C7-0469-48CD-B84E-38BD6518FDFA Q36212467-22AC0BD7-75D1-4973-882D-74D23B5D5654 Q36964327-E399897D-CE68-4D74-B4EC-822CE6E23EF3 Q37029584-A7B1165F-D072-4113-84E3-7D5CC7EB430E Q37046334-51F5CB1C-6C32-46D8-A8BB-0005DFCC63B9 Q37078239-C63745E4-54FD-4395-8F38-FBFA3B08405C Q37203685-CCE17776-72A1-42DD-97AE-32F3A6EFF271 Q37277222-7F5D8208-2FE1-4C9D-B226-F62D7ED9FAEF Q37317537-A310E6AF-139C-4321-AA49-B28B8DAB5623 Q37591953-B8C2AD7B-80D9-46D5-9D46-C4D9DA9434D3 Q37612810-AAFB5341-9A04-4E56-9611-04C9A0BDE519 Q37678205-92A93259-5802-40B8-A9F9-D47729F087EF Q37730342-5124D9B0-9BFC-4518-BF7E-E9A3C7E3656A Q38430701-8DA4347F-022C-4D49-B6CC-12488B62069B Q38432775-0CE8D490-D6C8-4F49-83FE-A3B72438DE4D Q38434020-AE1B555D-59CB-4020-AB3D-BE6BC9722E9B Q38642426-C480D2FA-E111-4A9A-ADF2-F2043F09AA6C Q38648719-E289B1BD-3483-4550-BFB9-734E6597063B Q38700519-99A554E5-BA80-49F8-BBA2-880AC8CE34DF Q38708887-717432E5-10E6-478F-9AE9-F262A8CFF99B Q38710688-A32D7CB5-34A9-417F-B5B6-A6100ED775B5 Q38735628-C3AE1C9F-87D2-4FAC-A871-064C83B60033 Q38755341-C07C7D4F-F2D0-4A19-88A9-8673BE7A3FD2 Q38755678-73017443-0FE4-41AA-B339-0194A04CC810 Q38763576-DDD5B0EF-80A5-4458-A2E1-C689C323E8AA

P2860

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

http://www.wikidata.org/entity/Q34045591

description

2015 nî lūn-bûn

@nan

2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@ast

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@en

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@nl

type

label

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@ast

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@en

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@nl

prefLabel

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@ast

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@en

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@nl

P1433

Q34045591-F05F21A7-CA5D-4D70-B86D-56740A71B56B

P1476

Q34045591-BA28D366-E85C-4548-95B1-5795DC75BBCD

P2093

Q34045591-00E91A8D-A1EC-42F9-925B-35933408EB2C

Q34045591-185CDA21-84A5-4E1E-9124-984963D84741

Q34045591-1EFF63B5-CD42-450B-B233-235B92A4F957

Q34045591-44046750-F5B5-4CC1-9FF7-2E5E4B5AE148

Q34045591-513F8CAB-EE3B-46E8-A8BA-AC1B97554ED5

Q34045591-55A6E7AA-CBEA-46AD-858F-A830A610E9DF

Q34045591-7A0193DF-764A-4A9D-BF53-EAEA837152E8

Q34045591-974F6D87-E7B8-42D3-9E65-C3A8785ACD05

Q34045591-D3F0B1BF-8804-4B75-93EA-6746530475FD

Q34045591-D55A0D3A-07E9-4A6E-977E-DC1FFCF7A5D0

P2860

Q34045591-029182DE-90BD-4749-AEE0-8936B5661B02

Q34045591-19D9024C-B0D4-4B46-9028-86779CCC4CD3

Q34045591-1F2DDD06-D837-401E-9B5F-8297503658A2

Q34045591-21EB874B-EB00-47E9-90A2-43F5CFA7CDD2

Q34045591-272E9607-2B30-44A3-8C21-E0C8DC5CCC7A

Q34045591-2BCF4CEF-EA8A-4C04-B866-9C9AE96388BD

Q34045591-2F0C5C6D-CCAD-497C-9FAC-A6AA30D689AA

Q34045591-3756B460-BDBD-4608-A5EE-812EA431F619

Q34045591-413C26A1-A087-4332-9D6D-24F0B334D5A9

Q34045591-43565D90-651D-4D5F-A281-2E9D9005E361

P2888

Q34045591-680E7F42-1831-4D61-B378-64F99EACC2DA

P304

Q34045591-123F568C-FC8B-4D33-B38C-B25B817F2491

P31

Q34045591-17BA43F5-FD83-4302-9DC5-562C85CDBB82

P356

Q34045591-883A977F-A62D-4BB9-A048-9B8D8084D133

P407

Q34045591-F2BD92FC-BABB-463B-8428-D1F4FA4ECD8B

P433

Q34045591-973B5BC3-AAE6-4E72-A6D2-638C073D3708

P478

Q34045591-3B49D9B0-5435-4493-BAC0-ECC997529D0E

P50

Q34045591-90B4F8A5-A310-4A4D-A3FC-352C9CFA2373

Q34045591-DFCB1B67-EB99-4568-884A-913CD7FD4230

P577

Q34045591-6E48CBEA-DD10-4E3C-B0B4-86E8C0E98038

P5875

Q34045591-EDEA1DAD-7617-4B07-B784-76FF4E3870A7

P698

Q34045591-6AA3E592-645E-4F1F-8D0E-63F6CA53A792

P932

Q34045591-02EBF519-2DC3-4502-AAAD-5B0A1BB21345

P356

P1433

Nature Medicine

P1476

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

@en

P2093

Aimin Meng

http://www.w3.org/2001/XMLSchema#string

Daohong Zhou

http://www.w3.org/2001/XMLSchema#string

Jianhui Chang

http://www.w3.org/2001/XMLSchema#string

Judith Campisi

http://www.w3.org/2001/XMLSchema#string

Kimberly Krager

http://www.w3.org/2001/XMLSchema#string

Krishnamurthy Janakiraman

http://www.w3.org/2001/XMLSchema#string

Lijian Shao

http://www.w3.org/2001/XMLSchema#string

Martin Hauer-Jensen

http://www.w3.org/2001/XMLSchema#string

Nukhet Aykin-Burns

http://www.w3.org/2001/XMLSchema#string

Remi-Martin Laberge

http://www.w3.org/2001/XMLSchema#string

P2860

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Short-term calorie restriction enhances skeletal muscle stem cell function

The central role of muscle stem cells in regenerative failure with aging

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Structure-guided design of a selective BCL-X(L) inhibitor

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

The serial cultivation of human diploid cell strains

The Bcl2 family: regulators of the cellular life-or-death switch

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

The senescence-associated secretory phenotype: the dark side of tumor suppression

P2888

P304

78-83

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NM.4010

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P50

Norman Sharpless

P577

2015-12-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

286984150

http://www.w3.org/2001/XMLSchema#string

P698

26657143

http://www.w3.org/2001/XMLSchema#string

P932

4762215

http://www.w3.org/2001/XMLSchema#string