Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice. - Wikidata - wikimedia - TriplyDB

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

http://www.wikidata.org/entity/Q34046144

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Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells Epigenetics and aging Small molecule compounds that induce cellular senescence Aging and adipose tissue: potential interventions for diabetes and regenerative medicine Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?Cellular senescence drives age-dependent hepatic steatosis.Senotherapy: growing old and staying young?Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.Cellular senescence mediates fibrotic pulmonary disease Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging.New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 Molecular pathology endpoints useful for aging studies.Targeting cellular senescence prevents age-related bone loss in mice.Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction.CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease.Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty.Cellular Senescence: A Translational Perspective.The Clinical Potential of Senolytic Drugs.Senescence in Health and Disease.Unbalanced Growth, Senescence and Aging.Senescent cells: an emerging target for diseases of ageing.Senescence in the aging process.Identification of HSP90 inhibitors as a novel class of senolytics.p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism.Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine.The senescent bystander effect is caused by ROS-activated NF-κB signalling.Phytochemical Study of Tapirira guianensis Leaves Guided by Vasodilatory and Antioxidant Activities.Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function.Identification of senescent cell surface targetable protein DPP4.Cellular senescence: Implications for metabolic disease.Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.Extracellular vesicles and aging.c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors.Cellular senescence biomarker p16INK4a+ cell burden in thigh adipose is associated with poor physical function in older women.The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?Source of Chronic Inflammation in Aging.

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P2860

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

http://www.wikidata.org/entity/Q34046144

description

2016 nî lūn-bûn

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2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2016年の論文

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2016年論文

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2016年論文

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2016年论文

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... aged or atherosclerotic mice.

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Chronic senolytic treatment al ...... n aged or atherosclerotic mice

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Bin Zhang

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Carolyn M Roos

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Grace Casaclang-Verzosa

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James L Kirkland

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Jordan D Miller

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Leslie A Smith

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Marissa J Schafer

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Michael Hagler

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Nassir M Thalji

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Tamar Pirtskhalava

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P2860

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence.

Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization.

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.

Endothelial function: a critical determinant in atherosclerosis?

Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).

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10.1111/ACEL.12458

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atherosclerosis

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