A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
about
Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assayInhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae FamiliesEbola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining stepProteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.Identification of a small-molecule entry inhibitor for filoviruses.Antiviral drugs specific for coronaviruses in preclinical developmentNovel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanismsChemical and Structural Aspects of Ebola Virus Entry Inhibitors.Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like proteaseEmerging paramyxoviruses: molecular mechanisms and antiviral strategiesPhosphatidylinositol 4-kinase IIIβ is required for severe acute respiratory syndrome coronavirus spike-mediated cell entryThe Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent.Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competenceSerological assays based on recombinant viral proteins for the diagnosis of arenavirus hemorrhagic fevers.Current approaches on viral infection: proteomics and functional validations.Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor.Development of novel entry inhibitors targeting emerging viruses.Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitorsActivity based protein profiling to detect serine hydrolase alterations in virus infected cellsHost cell factors in filovirus entry: novel players, new insightsEbola virus entry into host cells: identifying therapeutic strategies.Cathepsin B and L inhibitors: a patent review (2010 - present).Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection.A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species- and cell-type-specific manner.Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies.Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein.Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor.Candidate medical countermeasures targeting Ebola virus cell entry
P2860
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P2860
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@ast
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@en
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@nl
type
label
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@ast
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@en
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@nl
prefLabel
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@ast
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@en
A small-molecule oxocarbazate ...... n embryonic kidney 293T cells.
@nl
P2093
P2860
P50
P356
P1476
A small-molecule oxocarbazate ...... an embryonic kidney 293T cells
@en
P2093
Amos B Smith
Doron C Greenbaum
Huiyan Jing
Jeremy E Purvis
Michael C Myers
Parag P Shah
Scott L Diamond
Tianhua Wang
P2860
P304
P356
10.1124/MOL.110.064261
P577
2010-05-13T00:00:00Z