STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells.
about
A Central Role for STAT3 in Gammaherpesvirus-Life Cycle and -DiseasesScreening approaches to generating STAT inhibitors: Allowing the hits to identify the targetsRuxolitinib for symptom control in patients with chronic lymphocytic leukaemia: a single-group, phase 2 trial.Signal integration and gene induction by a functionally distinct STAT3 phosphoform.Immunohistochemical analysis of IL-6, IL-8/CXCR2 axis, Tyr p-STAT-3, and SOCS-3 in lymph nodes from patients with chronic lymphocytic leukemia: correlation between microvascular characteristics and prognostic significance.Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation.STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis.Deciphering STAT3 signaling in the heart: plasticity and vascular inflammation.Sulforhodamine B restaining as a whole-cell label allows visualizing one more fluorochrome and its application in assaying protein nucleocytoplasmic distribution.STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells.Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3.Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727.Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivoSignal transducer and activator of transcription-3 induces microRNA-155 expression in chronic lymphocytic leukemia.STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AMLMEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia.Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling.Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesotheliomaAberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells.Targeting the interleukin-6/Jak/stat pathway in human malignanciesRole of STAT3 in lung cancer.Inhibition of STAT3 reverses drug resistance acquired in temozolomide-resistant human glioma cells.Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotypeCellular calibrators to quantitate T-cell receptor excision circles (TRECs) in clinical samples.Metabolism pathways in chronic lymphocytic leukemia.Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress.At High Levels, Constitutively Activated STAT3 Induces Apoptosis of Chronic Lymphocytic Leukemia Cells.Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumorsPrognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemiaSTAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart.
P2860
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P2860
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@ast
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@en
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@nl
type
label
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@ast
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@en
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@nl
prefLabel
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@ast
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@en
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@nl
P2093
P2860
P50
P1433
P1476
STAT3 is constitutively phosph ...... es transcription in CLL cells.
@en
P2093
David Harris
Inbal Hazan-Halevy
Sreejesh Shanker
Xiaomin Chen
Zhiming Liu
P2860
P304
P356
10.1182/BLOOD-2009-10-230060
P407
P577
2010-02-12T00:00:00Z