CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range.
about
In vitro selection and evolution of functional proteins by using ribosome displayEliminating helper phage from phage displayAiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesStructure of an anti-blood group A Fv and improvement of its binding affinity without loss of specificityMolecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxinCrystal structure of a 3B3 variantâ A broadly neutralizing HIV-1 scFv antibodyMultivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycansCombining Yeast Display and Competitive FACS to Select Rare Hapten-Specific Clones from Recombinant Antibody LibrariesMF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines.Affinity maturation of antibodies assisted by in silico modeling.Isolation of anti-angiogenesis antibodies from a large combinatorial repertoire by colony filter screening.Improving antibody affinity by mimicking somatic hypermutation in vitro.Biological libraries.Thermodynamic consequences of grafting enhanced affinity toward the mutated antigen onto an antibody. The case of anti-lysozyme antibody, HyHEL-10.Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity.Generating recombinant anti-idiotypic antibodies for the detection of haptens in solution.Improvements to the Kunkel mutagenesis protocol for constructing primary and secondary phage-display libraries.Single-chain variable fragment antibodies against the neural adhesion molecule CHL1 (close homolog of L1) enhance neurite outgrowth.Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries.Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries.Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel.Antiacetylcholine receptor Fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies.A general method for greatly improving the affinity of antibodies by using combinatorial librariesAn affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Design of synthetic antibody libraries.Affinity-matured recombinant antibody fragments analyzed by single-molecule force spectroscopyAffinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating.Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening.Mining human antibody repertoires.The use of biosensor technology for the engineering of antibodies and enzymes.Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas.Production and characterization of a recombinant single-chain antibody against Hantaan virus envelop glycoprotein.Beyond natural antibodies: the power of in vitro display technologies.A novel VHH antibody targeting the B cell-activating factor for B-cell lymphoma.Structural consensus among antibodies defines the antigen binding sitePhages and HIV-1: from display to interplay.Detection of biomarkers using recombinant antibodies coupled to nanostructured platformsAffinity maturation of antiHER2 monoclonal antibody MIL5 using an epitope-specific synthetic phage library by computational design.Using phage and yeast display to select hundreds of monoclonal antibodies: application to antigen 85, a tuberculosis biomarker.Generating conformation-specific synthetic antibodies to trap proteins in selected functional states
P2860
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P2860
CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range.
description
1995 nî lūn-bûn
@nan
1995 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
CDR walking mutagenesis for th ...... body into the picomolar range.
@ast
CDR walking mutagenesis for th ...... body into the picomolar range.
@en
CDR walking mutagenesis for th ...... body into the picomolar range.
@nl
type
label
CDR walking mutagenesis for th ...... body into the picomolar range.
@ast
CDR walking mutagenesis for th ...... body into the picomolar range.
@en
CDR walking mutagenesis for th ...... body into the picomolar range.
@nl
prefLabel
CDR walking mutagenesis for th ...... body into the picomolar range.
@ast
CDR walking mutagenesis for th ...... body into the picomolar range.
@en
CDR walking mutagenesis for th ...... body into the picomolar range.
@nl
P2093
P356
P1476
CDR walking mutagenesis for th ...... body into the picomolar range.
@en
P2093
Barbas CF 3rd
Briones AT
Pinz-Sweeney S
P304
P356
10.1006/JMBI.1995.0626
P407
P577
1995-12-01T00:00:00Z