15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.
about
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cellsThe organization and consequences of eicosanoid signalingRole of prostaglandins in neuroinflammatory and neurodegenerative diseasesNew targets for the antitumor activity of gambogic acid in hematologic malignanciesThe electrophile responsive proteome: integrating proteomics and lipidomics with cellular functionCombined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemiaT-REX on-demand redox targeting in live cells.Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma.Increased expression ratio of Bcl-2/Bax is associated with crocin-mediated apoptosis in bovine aortic endothelial cells.Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation.Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Abeta42 reduces their differentiation potential.Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function.Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity.Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegenerationProstaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinasesInterleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2.Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death.The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator.Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration.Cyclooxygenase-2 enhances antimicrobial peptide expression and killing of Staphylococcus aureus.Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration.Molecular biological approaches to neurological disorders including knockout and transgenic mouse models.Isoprostane generation and function.Cell signalling by reactive lipid species: new concepts and molecular mechanisms.Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases.The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury.Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest.Increased generation of cyclopentenone prostaglandins after brain ischemia and their role in aggregation of ubiquitinated proteins in neurons15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.Protein disulfide isomerase as a novel target for cyclopentenone prostaglandins: implications for hypoxic ischemic injuryRegulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.Mitochondrial protein targets of thiol-reactive electrophiles15-Deoxy-Delta12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification.Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.
P2860
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P2860
15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@ast
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@en
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@nl
type
label
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@ast
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@en
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@nl
prefLabel
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@ast
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@en
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@nl
P2093
P2860
P356
P1476
15-Deoxy-Delta(12,14)-prostagl ...... at induces neuronal apoptosis.
@en
P2093
Koji Uchida
Makio Kobayashi
Makoto Iwata
Mitsuhiro Kondo
Noriko Noguchi
Noriyuki Shibata
Shoichi Sasaki
Takahiro Shibata
Takeshi Kumagai
Toshihiko Osawa
P2860
P304
P356
10.1073/PNAS.112212599
P407
P577
2002-05-01T00:00:00Z