Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases
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Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinasesProlonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistanceProstaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation.Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2.Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1.Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemiaComparative proteome analysis of abdominal adipose tissues between fat and lean broilers.Lubricin restoration in a mouse model of congenital deficiency.The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes.Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells.Mesothelin binding to CA125/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation.Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.Cytotoxic effects of 15d-PGJ2 against osteosarcoma through ROS-mediated AKT and cell cycle inhibition.Sialyl Lewisx-dependent binding of human monocyte-derived dendritic cells to selectins.Prostaglandins antagonistically control Bax activation during apoptosisProstaglandins and rheumatoid arthritis.
P2860
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P2860
Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@ast
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@en
type
label
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@ast
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@en
prefLabel
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@ast
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@en
P2093
P2860
P356
P1476
Prostaglandin (PG)D(2) and 15- ...... egulation of polo-like kinases
@en
P2093
A Kontrogianni-Konstantopoulos
K Konstantopoulos
P2860
P2888
P304
P356
10.1038/CDD.2010.13
P577
2010-02-12T00:00:00Z
P5875
P6179
1012628687