Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.
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Specialized Functional Diversity and Interactions of the Na,K-ATPaseVisualizing functional motions of membrane transporters with molecular dynamics simulationsInteractions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding ModesExploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computationCommon Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion ChannelStructure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic KetamineMultisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)Molecular mechanism for the dual alcohol modulation of Cys-loop receptorsBringing Clarity to the Prediction of Protein-Ligand Binding Free Energies via "Blurring"Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesModeling and simulation of ion channels.Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations.Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanismsA membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.General anesthetics predicted to block the GLIC pore with micromolar affinity.Atomistic models of general anesthetics for use in in silico biological studiesHigh-Throughput parallel blind Virtual Screening using BINDSURF.Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation.Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.Discovery of a novel general anesthetic chemotype using high-throughput screening.Conformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.Isoflurane alters the structure and dynamics of GLIC.Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.Drying transition in the hydrophobic gate of the GLIC channel blocks ion conductionNovel activation of voltage-gated K(+) channels by sevoflurane.GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChRCommon Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion ChannelsAsymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sitesShaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anestheticsMuscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.All the O2 Consumed by Thermus thermophilus Cytochrome ba3 Is Delivered to the Active Site through a Long, Open Hydrophobic Tunnel with Entrances within the Lipid Bilayer.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Assembly of nicotinic and other Cys-loop receptors.Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.Pentameric Ligand-gated Ion Channels : Insights from Computation.Computational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function.Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins.Conditions that Stabilize Membrane Domains Also Antagonize n-Alcohol Anesthesia
P2860
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P2860
Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Multiple binding sites for the ...... receptor transmembrane domain.
@ast
Multiple binding sites for the ...... receptor transmembrane domain.
@en
Multiple binding sites for the ...... receptor transmembrane domain.
@nl
type
label
Multiple binding sites for the ...... receptor transmembrane domain.
@ast
Multiple binding sites for the ...... receptor transmembrane domain.
@en
Multiple binding sites for the ...... receptor transmembrane domain.
@nl
prefLabel
Multiple binding sites for the ...... receptor transmembrane domain.
@ast
Multiple binding sites for the ...... receptor transmembrane domain.
@en
Multiple binding sites for the ...... receptor transmembrane domain.
@nl
P2860
P50
P356
P1476
Multiple binding sites for the ...... receptor transmembrane domain.
@en
P2093
David N LeBard
Michael L Klein
P2860
P304
14122-14127
P356
10.1073/PNAS.1008534107
P407
P577
2010-07-26T00:00:00Z