Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
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The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleusPAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinContribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic micePresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationMetabolic syndrome and the role of dietary lifestyles in Alzheimer's diseaseMolecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithmsPlatelets and Alzheimer's disease: Potential of APP as a biomarkerRegulation of distinct pools of amyloid β-protein by multiple cellular proteasesPresenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of NotchSpotlight on BACE: the secretases as targets for treatment in Alzheimer diseaseRecent advances: PsychiatryProtein structure validation and identification from unassigned residual dipolar coupling data using 2D-PDPA.Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia.Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration.Alzheimer disease models and human neuropathology: similarities and differencesConstruction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to beta-secretase.Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling.Proteolysis in Alzheimer's disease. Can plasmin tip the balance?A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafishThe intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.Notch receptor cleavage depends on but is not directly executed by presenilins.Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 productionCombined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.Obovatol improves cognitive functions in animal models for Alzheimer's disease.Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor.Secretases as targets for drug design in Alzheimer's disease.Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice.Genetics of Alzheimer's disease: a centennial reviewSearching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stressPhosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.Bacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease.gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's disease.Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Association of ApoE and LRP mRNA levels with dementia and AD neuropathology.Remodelling of Ca2+ homeostasis in type I cortical astrocytes by hypoxia: evidence for association with Alzheimer's disease.Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model.
P2860
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P2860
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@ast
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@en
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@nl
type
label
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@ast
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@en
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@nl
prefLabel
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@ast
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@en
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@nl
P1433
P1476
Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
@en
P2093
P304
P356
10.1016/S0896-6273(00)00051-9
P407
P577
2000-09-01T00:00:00Z