Recognizing and exploiting differences between RNAi and small-molecule inhibitors. - Wikidata - wikimedia - TriplyDB

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

http://www.wikidata.org/entity/Q34074675

about

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells Open access chemical probes for epigenetic targets Small-molecule based musculoskeletal regenerative engineering Chemical probes of histone lysine methyltransferases Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth Chemical genetic strategy for targeting protein kinases based on covalent complementarity Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.Synthetic lethality: emerging targets and opportunities in melanoma.Prostanoid receptor EP2 as a therapeutic target A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.Probing the probes: fitness factors for small molecule tools.Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells.Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations.Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.Target validation using chemical probes.Evaluating the feasibility of utilizing the small molecule phenamil as a novel biofactor for bone regenerative engineering.The role of small molecules in musculoskeletal regeneration.Unraveling the mechanism of cell death induced by chemical fibrils.The Plk1-dependent phosphoproteome of the early mitotic spindle The promise and peril of chemical probes.An activating transcription factor 5-mediated survival pathway as a target for cancer therapy?Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart.Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia.Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation.Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C Combining targeted therapies: practical issues to consider at the bench and bedside.Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex Ligand and Target Discovery by Fragment-Based Screening in Human Cells.A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.

P2860

Q24304441-7FD78850-9862-4EC1-8F6D-94DCFB10D99C Q26781872-FD0D72FC-46AB-466E-8021-00C8963FAE2A Q26821892-8FF38B45-9CDF-4FB8-8FBB-BD94850FB327 Q26829218-F2CC009C-AA22-4E29-9E64-2F1BFC1E8691 Q27012561-323D1951-5C93-4E6B-8F47-A7F90F9B12C4 Q27660385-1F85B7EC-53F1-492D-BC99-BAEA4D83D1BD Q27661276-427BB3F7-9BDE-4521-A651-A2C68CB1405E Q27671824-C40DF6A3-0486-401E-A19E-5210C3D0E284 Q28468631-2F039B7A-8533-4BD2-9200-8738AB98B7F0 Q28545089-73A1874E-C63E-4722-BEA2-A8C89F9B679F Q28554718-EE8BF42B-501D-4DB5-BD06-A20B770519F6 Q28830245-23B2C68C-14D9-4DBF-ABEB-58F02B9CB597 Q33575787-7B96E94B-C445-4B44-B201-C2AB75CDC7AA Q33578398-D5C62ABD-06DB-4427-B20B-0785A5A60E7D Q33711678-815D2713-A04A-43F5-A293-D2D4925767A6 Q33900952-D6540B2D-D0A2-4507-8664-05C5AFF61464 Q34001269-AB7D66D4-C14D-4947-97DB-42BB98680BE6 Q34068144-9DFD6B6A-AD56-4ACD-AEF4-C3D679F59746 Q34097567-E2F2F822-F728-4323-9762-6E680CA83C81 Q34290756-11211F83-55E8-4655-A890-7552D4752B79 Q34333826-2634F6F6-CE76-4259-822A-B9D4B28C208A Q34344443-6DB067F6-883A-4EC8-92E1-D1677A325B26 Q34346326-9B04271E-DC68-4D29-AA3C-8DDBCE651938 Q34364152-58C5C3C2-7204-4FF0-9920-1650FF41C27D Q34454981-C58E5299-7F06-4A42-9B5B-FCD71AD44A3D Q34486195-1724A55E-3C20-4516-A18F-444371DAA0BE Q34754478-6FE1584B-A2F6-4B05-99FA-A665BE2E3D0B Q35086234-5DF36041-3D11-44E6-8012-996457F3C0CA Q35149824-5F8BC7DF-47B2-40BA-AE37-72D4898EF290 Q35377412-48D3A1E3-1399-4358-959E-12EDDCE47860 Q35532881-7C7F2B7B-640A-4D1B-8D97-6F826CB9723C Q35583672-621FC5F0-F437-41DA-BF11-2F1C63D6F645 Q35894216-945CCC3A-35AD-4C7F-B873-5EF6A267BE7E Q36022324-A27E6ECE-D29C-412B-A908-F6A85E94E4BA Q36080184-9F8941F4-2BC1-4BF2-99ED-77F3DCD44512 Q36110068-9CF44E10-FC58-4BB8-BD66-B87AE95DB384 Q36163451-46C1C2B7-9A75-4C6D-8AB8-FA341EF5D0FD Q36256789-E1B6A90B-4248-4EC8-8381-09506F123938 Q36283537-3B29C775-4568-422C-AE21-DACC236C04BD Q36739419-D411D9AB-F1EC-439C-B03A-C0B0C28AA361

P2860

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

http://www.wikidata.org/entity/Q34074675

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@ast

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@en

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@nl

type

label

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@ast

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@en

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@nl

prefLabel

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@ast

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@en

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@nl

P1433

Q34074675-D96C6647-30CC-4B7F-BD68-BC37D074B9A8

P1476

Q34074675-37B724A4-AA9C-4DD0-85A9-8F407DC6CF97

P2093

Q34074675-79703D75-2D2E-44B8-8A5B-308040FBB219

Q34074675-84D13662-2996-424B-AA9E-4DC505E7EBA0

Q34074675-98BEA0DD-8EC3-419A-93E6-2E7C6937417D

P2860

Q34074675-056F27A3-E2A6-40FF-A358-D79C2A2C3048

Q34074675-06F5FF16-548B-45E5-8863-11776E352E3F

Q34074675-07003231-1C0D-4820-B2DC-4DE8030A9E93

Q34074675-0A278F91-D933-45F6-8151-A908BC91ADDC

Q34074675-1DCA0AF6-77B6-487B-8E7F-C6CA94E4E31F

Q34074675-2A7DCB22-AC67-4144-A3A7-90CF7CAA7893

Q34074675-2BDA0FA7-0CD0-433A-A292-12131ABD93A1

Q34074675-36ABC30F-DBDF-4C82-A4BC-FCCA3079971E

Q34074675-4D31E775-48B6-41DC-BBBD-7E564154B6D6

Q34074675-5692D964-2EA5-46B5-BDA3-4924F1563B77

P2888

Q34074675-147DD82C-FA3E-46E4-BD6C-849077BC2E70

P304

Q34074675-FCBDDDB1-0E5C-46EB-BB9B-A8E5C0B267D8

P31

Q34074675-393360C8-D9AD-41F3-9F98-03F2AFA1D575

P356

Q34074675-25AF3431-CFCE-45D9-B42C-648C598EB706

P433

Q34074675-254A1F67-F592-4CD6-87A1-A99A0B49D50B

P478

Q34074675-D36BFCE5-B5EC-4E98-9682-323C3F883932

P577

Q34074675-021CD474-22D2-44B1-89CF-0291E6348E84

P5875

Q34074675-7A5913B1-A007-4BE6-89E5-AF5DD9998241

P6179

Q34074675-569EC770-0D45-46E7-992E-D0C6E85ED706

P698

Q34074675-72EF9244-005E-4119-B826-15F9FA84AF1F

P932

Q34074675-1C3E33DB-CA41-49B7-B8BB-CCB0F2EA424F

P356

NCHEMBIO1207-739

P1433

Nature Chemical Biology

P1476

Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

@en

P2093

Kevan M Shokat

http://www.w3.org/2001/XMLSchema#string

Stephen S Taylor

http://www.w3.org/2001/XMLSchema#string

William A Weiss

http://www.w3.org/2001/XMLSchema#string

P2860

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

Strategies for silencing human disease using RNA interference

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

P2888

nchembio1207-739

P304

739-744

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NCHEMBIO1207-739

http://www.w3.org/2001/XMLSchema#string

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P577

2007-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5838740

http://www.w3.org/2001/XMLSchema#string

P6179

1050191010

http://www.w3.org/2001/XMLSchema#string

P698

18007642

http://www.w3.org/2001/XMLSchema#string

P932

2924165

http://www.w3.org/2001/XMLSchema#string