HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. - Wikidata - wikimedia - TriplyDB

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.

http://www.wikidata.org/entity/Q34085119

about

Vaccine adjuvants: mode of action Role of Toll-like receptors in adjuvant-augmented immune therapies.Toll-like receptors: the swiss army knife of immunity and vaccine development Nonhuman primate models for HIV/AIDS vaccine development Mechanisms of HIV protein degradation into epitopes: implications for vaccine design Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants TLR8: the forgotten relative revindicated A Tetravalent Sub-unit Dengue Vaccine Formulated with Ionizable Cationic Lipid Nanoparticle induces Significant Immune Responses in Rodents and Non-Human Primates Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques Toll-Like Receptors and Viruses: Induction of Innate Antiviral Immune Responses Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV Harnessing the Microbiome to Enhance Cancer Immunotherapy Immune Adjuvant Effect of Molecularly-defined Toll-Like Receptor Ligands Programming the magnitude and persistence of antibody responses with innate immunity.Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering Autocrine production of beta-chemokines protects CMV-Specific CD4 T cells from HIV infection Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity.Modulation of adaptive immunity with Toll-like receptors FimH can directly activate human and murine natural killer cells via TLR4 Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specific immune responses.Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2.Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants Immune-based approaches to the prevention of mother-to-child transmission of HIV-1: active and passive immunization.TLR-based immune adjuvants.Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates.A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants.Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity TLR8 agonists stimulate newly recruited monocyte-derived cells into potent APCs that enhance HBsAg immunogenicity.Dendritic-cell interactions with HIV: infection and viral dissemination.The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.Challenges in the development of an HIV-1 vaccine.Resiquimod and other immune response modifiers as vaccine adjuvants.Humoral responses against coimmunized protein antigen but not against alphavirus-encoded antigens require alpha/beta interferon signaling The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses.

P2860

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HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates.

http://www.wikidata.org/entity/Q34085119

description

2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

HIV Gag protein conjugated to ...... esponses in nonhuman primates.

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HIV Gag protein conjugated to ...... esponses in nonhuman primates.

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HIV Gag protein conjugated to ...... esponses in nonhuman primates.

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HIV Gag protein conjugated to ...... esponses in nonhuman primates.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

HIV Gag protein conjugated to ...... esponses in nonhuman primates.

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P2093

Barbara J Flynn

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Karin Loré

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Mario Roederer

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Richard A Koup

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Robert A Seder

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Ross M Kedl

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Ulrike Wille-Reece

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Walter R Weiss

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P2860

Toll-like receptors

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.

Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

Mouse and human dendritic cell subtypes.

Exploiting dendritic cells to improve vaccine efficacy.

Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene

Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens.

Modulating vaccine responses with dendritic cells and Toll-like receptors.

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation

Interferon-producing cells fail to induce proliferation of naive T cells but can promote expansion and T helper 1 differentiation of antigen-experienced unpolarized T cells.

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15190-15194

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scholarly article

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10.1073/PNAS.0507484102

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P407

P433

42

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P478

102

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P50

Joseph J Mattapallil

P577

2005-10-11T00:00:00Z

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7545853

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16219698

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P921

Toll-like receptor

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1257732

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