Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation.
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Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9Protein kinase C delta blocks immediate-early gene expression in senescent cells by inactivating serum response factorCellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complexAlpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblastsRottlerin and cancer: novel evidence and mechanismsPKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damageProtein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neuronsProtein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathwayP2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase CPhorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts.Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties.TRB3 is involved in free fatty acid-induced INS-1-derived cell apoptosis via the protein kinase C δ pathwayGenetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formationA differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cellsCGX1037 is a novel PKC isoform delta selective inhibitor in platelets.Structural basis of protein kinase C isoform functionPKC-δ mediates interferon-α-induced apoptosis through c-Jun NH₂-terminal kinase activation.Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasionRottlerin Inhibits Lonicera japonica-Induced Photokilling in Human Lung Cancer Cells through Cytoskeleton-Related Signaling Cascade.Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-deltaVaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture.Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism.Role of protein kinase C in caerulein induced expression of substance P and neurokinin-1-receptors in murine pancreatic acinar cellsDual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibilityDifferential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells.The Unfolded Protein Response Plays a Predominant Homeostatic Role in Response to Mitochondrial Stress in Pancreatic Stellate Cells.Distinctive activation mechanisms and functions for protein kinase Cdelta.Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells.Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats.The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin.Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane.Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging.A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells.
P2860
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P2860
Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
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2001年學術文章
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name
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@ast
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@en
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@nl
type
label
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@ast
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@en
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@nl
prefLabel
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@ast
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@en
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@nl
P356
P1476
Rottlerin is a mitochondrial u ...... elta tyrosine phosphorylation.
@en
P2093
Soltoff SP
P304
37986-37992
P356
10.1074/JBC.M105073200
P407
P577
2001-08-09T00:00:00Z