Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice. - Wikidata - wikimedia - TriplyDB

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

http://www.wikidata.org/entity/Q34091331

about

Polycystic liver diseases: advanced insights into the molecular mechanisms Experimental therapies and ongoing clinical trials to slow down progression of ADPKD Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases.Inhibition of the P2X7 receptor reduces cystogenesis in PKD.Anti-proliferation effects of Sirolimus sustained delivery film in rabbit glaucoma filtration surgery.Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease.Vasopressin and disruption of calcium signalling in polycystic kidney disease.Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.mTOR activates hypoxia-inducible factor-1α and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia.Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases.Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms.Autocrine regulation of biliary pathology by activated cholangiocytes.Urinary MCP1 and Microalbumin increase prior to onset of Azotemia in mice with polycystic kidney disease.Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases.Epithelial-mesenchymal interactions in biliary diseases Polycystic liver diseases: congenital disorders of cholangiocyte signaling Systematic review: the pathophysiology and management of polycystic liver disease.Development of the bile ducts: essentials for the clinical hepatologist.Diagnosis and management of polycystic liver disease.Vascular biology of the biliary epithelium Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes.Therapeutic Targets in Polycystic Liver Disease.Podocyte directed therapy of nephrotic syndrome-can we bring the inside out?An overview of experimental and early investigational therapies for the treatment of polycystic kidney disease.Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease.Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation.An update on the pathophysiology and management of polycystic liver disease.Animal models of biliary injury and altered bile acid metabolism.The role of microRNAs in neural stem cell-supported endothelial morphogenesis.Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes.Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.Hyperosmotic stress stimulates autophagy via polycystin-2.Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.Vascular endothelial growth factors in progenitor cells mediated liver repair.Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.

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Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

http://www.wikidata.org/entity/Q34091331

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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Mammalian target of rapamycin ...... n polycystin-2-defective mice.

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Mammalian target of rapamycin ...... n polycystin-2-defective mice.

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Mammalian target of rapamycin ...... n polycystin-2-defective mice.

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Mammalian target of rapamycin ...... n polycystin-2-defective mice.

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Mammalian target of rapamycin ...... n polycystin-2-defective mice.

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Mammalian target of rapamycin ...... n polycystin-2-defective mice.

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Mammalian target of rapamycin ...... in polycystin-2-defective mice

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Carlo Spirli

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Luca Fabris

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Mario Strazzabosco

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Romina Fiorotto

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Silvia Lecchi

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Stefan Somlo

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Stefano Okolicsanyi

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Xin Tian

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P2860

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

TOR signaling in growth and metabolism

Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis

Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases

Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

Estrogens and the pathophysiology of the biliary tree

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy.

ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.

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1778-1788

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10.1002/HEP.23511

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5

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51

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Massimiliano Cadamuro

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2010-05-01T00:00:00Z

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41406280

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20131403

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2930014

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