Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates
about
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingRhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signalingThe α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1uExosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysisThe roles of intramembrane proteases in protozoan parasitesShedding of TRAP by a rhomboid protease from the malaria sporozoite surface is essential for gliding motility and sporozoite infectivityThe structural basis for catalysis and substrate specificity of a rhomboid proteaseStructure of Rhomboid Protease in a Lipid EnvironmentActivity-based probes for rhomboid proteases discovered in a mass spectrometry-based assayLarge Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane ProteaseStructure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ CavityConformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ SubsitesProteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate AffinityAllosteric regulation of rhomboid intramembrane proteolysisDivIC stabilizes FtsL against RasP cleavageA Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host CellsMitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARLStructure and mechanism of rhomboid proteaseMonocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteasesJuxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodiesGlyGly-CTERM and rhombosortase: a C-terminal protein processing signal in a many-to-one pairing with a rhomboid family intramembrane serine proteaseMammalian EGF receptor activation by the rhomboid protease RHBDL2Sharpening rhomboid specificity by dimerisation and allostery.A rhomboid protease gene deletion affects a novel oligosaccharide N-linked to the S-layer glycoprotein of Haloferax volcaniiSubstrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structuresSecretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.A subset of membrane-altering agents and γ-secretase modulators provoke nonsubstrate cleavage by rhomboid proteasesIntramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.Membrane proteases in the bacterial protein secretion and quality control pathway.Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway.Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode.Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavageThe membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility.Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases.Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics.Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFαCryptosporidium parvum rhomboid1 has an activity in microneme protein CpGP900 cleavage.Trafficking of the EGFR ligand Spitz regulates its signaling activity in polarized tissues.
P2860
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P2860
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Sequence-specific intramembran ...... n motif in rhomboid substrates
@ast
Sequence-specific intramembran ...... n motif in rhomboid substrates
@en
Sequence-specific intramembran ...... n motif in rhomboid substrates
@nl
type
label
Sequence-specific intramembran ...... n motif in rhomboid substrates
@ast
Sequence-specific intramembran ...... n motif in rhomboid substrates
@en
Sequence-specific intramembran ...... n motif in rhomboid substrates
@nl
prefLabel
Sequence-specific intramembran ...... n motif in rhomboid substrates
@ast
Sequence-specific intramembran ...... n motif in rhomboid substrates
@en
Sequence-specific intramembran ...... n motif in rhomboid substrates
@nl
P2860
P1433
P1476
Sequence-specific intramembran ...... n motif in rhomboid substrates
@en
P2093
Kvido Strisovsky
Matthew Freeman
P2860
P304
P356
10.1016/J.MOLCEL.2009.11.006
P577
2009-12-01T00:00:00Z