Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy - Wikidata - wikimedia - TriplyDB

Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy

Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy

http://www.wikidata.org/entity/Q34094086

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Calsequestrin 2 and arrhythmias Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes Formation of spatially discordant alternans due to fluctuations and diffusion of calcium Current topics in catecholaminergic polymorphic ventricular tachycardia Calsequestrin mutations and catecholaminergic polymorphic ventricular tachycardia Genetics of sudden cardiac death syndromes Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia.Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutation Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry?The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load.A model of canine purkinje cell electrophysiology and Ca(2+) cycling: rate dependence, triggered activity, and comparison to ventricular myocytes.Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.The ionic bases of the action potential in isolated mouse cardiac Purkinje cell Cardiac cellular coupling and the spread of early instabilities in intracellular Ca2+.Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2.Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.Phenotypically silent Cre recombination within the postnatal ventricular conduction system Cardiac ion channelopathies and the sudden infant death syndrome Calcium alternans in cardiac myocytes: order from disorder.Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles.Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies.Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia Transcription factor ETV1 is essential for rapid conduction in the heart.Genetics of sudden death: focus on inherited channelopathies.Targeting ryanodine receptors for anti-arrhythmic therapy.Cardiac conduction system anomalies and sudden cardiac death: insights from murine models.Electrical storm: recent pathophysiological insights and therapeutic consequences.Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application.Ventricular arrhythmias and the His-Purkinje system.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.Extinguishing intracellular calcium leak: a promising antiarrhythmic approach.Development and Function of the Cardiac Conduction System in Health and Disease.Evoked centripetal Ca(2+) mobilization in cardiac Purkinje cells: insight from a model of three Ca(2+) release regions.Catecholaminergic polymorphic ventricular tachycardia, an update.

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Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy

http://www.wikidata.org/entity/Q34094086

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

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CIRCRESAHA.110.221481

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Circulation Research

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Purkinje cells from RyR2 mutan ...... responsive to targeted therapy

@en

P2093

Fang-Yu Liu

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Glenn I Fishman

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Guoxin Kang

http://www.w3.org/2001/XMLSchema#string

Jie Zhang

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Nian Liu

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Silvia G Priori

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Steven F Giovannone

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P2860

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel

Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)

Catecholaminergic polymorphic ventricular tachycardia

Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

Ca(2+) transients and Ca(2+) waves in purkinje cells : role in action potential initiation.

Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes.

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512-519

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scholarly article

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10.1161/CIRCRESAHA.110.221481

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4

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107

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2010-07-01T00:00:00Z

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44902147

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20595652

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2930621

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