Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy
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Calsequestrin 2 and arrhythmiasChannel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular CardiomyocytesFormation of spatially discordant alternans due to fluctuations and diffusion of calciumCurrent topics in catecholaminergic polymorphic ventricular tachycardiaCalsequestrin mutations and catecholaminergic polymorphic ventricular tachycardiaGenetics of sudden cardiac death syndromesSudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia.Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.In situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutationAtrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry?The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load.A model of canine purkinje cell electrophysiology and Ca(2+) cycling: rate dependence, triggered activity, and comparison to ventricular myocytes.Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cellsUnique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation.The ionic bases of the action potential in isolated mouse cardiac Purkinje cellCardiac cellular coupling and the spread of early instabilities in intracellular Ca2+.Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2.Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.Phenotypically silent Cre recombination within the postnatal ventricular conduction systemCardiac ion channelopathies and the sudden infant death syndromeCalcium alternans in cardiac myocytes: order from disorder.Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles.Accelerated sinus rhythm prevents catecholaminergic polymorphic ventricular tachycardia in mice and in patients.Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies.Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular TachycardiaTranscription factor ETV1 is essential for rapid conduction in the heart.Genetics of sudden death: focus on inherited channelopathies.Targeting ryanodine receptors for anti-arrhythmic therapy.Cardiac conduction system anomalies and sudden cardiac death: insights from murine models.Electrical storm: recent pathophysiological insights and therapeutic consequences.Pharmacotherapy for inherited arrhythmia syndromes: mechanistic basis, clinical trial evidence and practical application.Ventricular arrhythmias and the His-Purkinje system.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.Extinguishing intracellular calcium leak: a promising antiarrhythmic approach.Development and Function of the Cardiac Conduction System in Health and Disease.Evoked centripetal Ca(2+) mobilization in cardiac Purkinje cells: insight from a model of three Ca(2+) release regions.Catecholaminergic polymorphic ventricular tachycardia, an update.
P2860
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P2860
Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@ast
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@en
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@nl
type
label
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@ast
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@en
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@nl
prefLabel
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@ast
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@en
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@nl
P2093
P2860
P1433
P1476
Purkinje cells from RyR2 mutan ...... responsive to targeted therapy
@en
P2093
Fang-Yu Liu
Glenn I Fishman
Guoxin Kang
Silvia G Priori
Steven F Giovannone
P2860
P304
P356
10.1161/CIRCRESAHA.110.221481
P577
2010-07-01T00:00:00Z