Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin
about
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunctionMechanisms of sudden unexplained death in epilepsyThe catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerizationNovel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.Variability in timing of spontaneous calcium release in the intact rat heart is determined by the time course of sarcoplasmic reticulum calcium load.Targeting intracellular calcium cycling in catecholaminergic polymorphic ventricular tachycardia: a theoretical investigation.Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes.Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutationsDysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapyIn situ confocal imaging in intact heart reveals stress-induced Ca(2+) release variability in a murine catecholaminergic polymorphic ventricular tachycardia model of type 2 ryanodine receptor(R4496C+/-) mutationSpontaneous Ca2+ sparks and Ca2+ homeostasis in a minimal model of permeabilized ventricular myocytes.A mathematical model of spontaneous calcium release in cardiac myocytesEndoplasmic reticulum Ca(2+) handling in excitable cells in health and diseaseRecovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity.Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium SignalingSarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.Calsequestrin 2 deletion shortens the refractoriness of Ca²⁺ release and reduces rate-dependent Ca²⁺-alternans in intact mouse hearts.Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies.Practice viewpoints: AICD, who and when?Sudden unexpected death in epilepsy genetics: Molecular diagnostics and preventionNew roles of calsequestrin and triadin in cardiac muscle.Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation.Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion.Calcium polymorphic ventricular tachycardia: a new name for CPVT?Increased Ca(2+) leak and spatiotemporal coherence of Ca(2+) release in cardiomyocytes during beta-adrenergic stimulation.Role of coupled gating between cardiac ryanodine receptors in the genesis of triggered arrhythmias.Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814.Systems and synthetic biology approaches in understanding biological oscillators.
P2860
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P2860
Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@ast
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@en
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@nl
type
label
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@ast
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@en
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@nl
prefLabel
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@ast
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@en
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@nl
P356
P1476
Disruption of calcium homeosta ...... ine receptor and calsequestrin
@en
P2093
Silvia G Priori
P304
P356
10.1093/CVR/CVM004
P407
P577
2008-01-15T00:00:00Z