Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene
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Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilizationMacrophage TGF-β1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic ConditionsComparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) geneThe autolysis of human HtrA1 is governed by the redox state of its N-terminal domainThe insoluble TGFBIp fraction of the cornea is covalently linked via a disulfide bond to type XII collagenSerine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid depositsLysosomal trafficking of TGFBIp via caveolae-mediated endocytosis.Fibril Core of Transforming Growth Factor Beta-Induced Protein (TGFBIp) Facilitates Aggregation of Corneal TGFBIp.Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2.The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferationPolymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q MutantsAltered protein conformation and lower stability of the dystrophic transforming growth factor beta-induced protein mutants.The Human Eye Proteome Project: perspectives on an emerging proteome.Determinants of amyloid fibril degradation by the PDZ protease HTRA1.Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patientsLASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).The Human Eye Proteome Project: Updates on an Emerging Proteome.Amyloid assembly and disassembly
P2860
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P2860
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene
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2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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Composition and proteolytic pr ...... th mutations in the TGFBI gene
@ast
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@en
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@nl
type
label
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@ast
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@en
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@nl
prefLabel
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@ast
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@en
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@nl
P2093
P2860
P1476
Composition and proteolytic pr ...... th mutations in the TGFBI gene
@en
P2093
Gordon K Klintworth
Henrik Karring
Ida B Thøgersen
Jan J Enghild
Kasper Runager
Peter Højrup
P2860
P304
P356
10.1016/J.EXER.2011.11.014
P577
2011-12-03T00:00:00Z